In vitro activity of 18 antimicrobial agents against clinical isolates of Acinetobacter spp. : multicenter national study GEIH-REIPI-Ab 2010
Copyright © 2012 Elsevier España, S.L. All rights reserved..
OBJECTIVES: To determine the prevalence of resistance to antimicrobials in Acinetobacter baumannii (A. baumannii) from Spain and to compare it with those obtained in the first national study (GEIH-Ab project 2000).
METHODS: A total of 446 isolates of A. baumannii obtained from 43 Spanish hospitals during February-March 2010 were studied. Identification of A. baumannii was confirmed by ARDRA and MALDI-TOF. Susceptibility to 18 antimicrobial agents was determined by microdilution (Clinical and Laboratory Standards Institute, CLSI). The CLSI break-points were used, except for doripenem, rifampin, sulbactam (Societé Française de Microbiologie [SFM] break-points) and tigecycline (European Committee on Antimicrobial Susceptibility Testing [EUCAST] break-points for Enterobacteriaceae).
RESULTS: The percentage of resistant isolates (intermediate susceptible plus resistant) was: > 94% (ceftazidime, piperacillin and ciprofloxacin), 82-86% (carbapenems, tetracycline), 60-70% (tobramycin, sulbactam, gentamicin, doxycycline), 49% (amikacin), 30% (minocycline, rifampin), 24% (tigecycline), and 3% (colistin). These isolates were, in comparison with those of the first study, more resistant (P < .01) to ceftazidime (99% vs 83%), carbapenems (82-86% vs 43-48%), sulbactam (65% vs 53%) and colistin (3% vs 0%), but more susceptible to aminoglycosides (particularly gentamicin: 70% vs 96% of resistant isolates), tetracycline (83% vs 91%) and rifampicin (30% vs 51%).
CONCLUSION: There is a high prevalence of A. baumannii resistant to antimicrobials, particularly to carbapenems. The resistance to carbapenems, ceftazidime and sulbactam was significantly higher than that observed for isolates from the GEIH-Ab project 2000. The resistance to aminoglycosides, tetracycline and rifampin, however, was significantly decreased.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
Enfermedades infecciosas y microbiologia clinica - 31(2013), 1 vom: 29. Jan., Seite 4-9 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Actividad de 18 agentes antimicrobianos frente a aislados clínicos de Acinetobacter baumannii: segundo estudio nacional multicéntrico (proyecto GEIH-REIPI-Ab 2010) |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 06.01.2014 Date Revised 18.03.2022 published: Print-Electronic ErratumIn: Enferm Infecc Microbiol Clin. 2013 May;31(5):353 Pizarraya, Antonio Gutiérrez [added]; Marquez Vacaro, Juan Antonio [added]; Montero, José Garnacho [added] Citation Status MEDLINE |
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| doi: |
10.1016/j.eimc.2012.06.010 |
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| 245 | 1 | 0 | |a In vitro activity of 18 antimicrobial agents against clinical isolates of Acinetobacter spp. |b multicenter national study GEIH-REIPI-Ab 2010 |
| 246 | 3 | 3 | |a Actividad de 18 agentes antimicrobianos frente a aislados clínicos de Acinetobacter baumannii: segundo estudio nacional multicéntrico (proyecto GEIH-REIPI-Ab 2010) |
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| 500 | |a Date Completed 06.01.2014 | ||
| 500 | |a Date Revised 18.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Enferm Infecc Microbiol Clin. 2013 May;31(5):353 Pizarraya, Antonio Gutiérrez [added]; Marquez Vacaro, Juan Antonio [added]; Montero, José Garnacho [added] | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2012 Elsevier España, S.L. All rights reserved. | ||
| 520 | |a OBJECTIVES: To determine the prevalence of resistance to antimicrobials in Acinetobacter baumannii (A. baumannii) from Spain and to compare it with those obtained in the first national study (GEIH-Ab project 2000) | ||
| 520 | |a METHODS: A total of 446 isolates of A. baumannii obtained from 43 Spanish hospitals during February-March 2010 were studied. Identification of A. baumannii was confirmed by ARDRA and MALDI-TOF. Susceptibility to 18 antimicrobial agents was determined by microdilution (Clinical and Laboratory Standards Institute, CLSI). The CLSI break-points were used, except for doripenem, rifampin, sulbactam (Societé Française de Microbiologie [SFM] break-points) and tigecycline (European Committee on Antimicrobial Susceptibility Testing [EUCAST] break-points for Enterobacteriaceae) | ||
| 520 | |a RESULTS: The percentage of resistant isolates (intermediate susceptible plus resistant) was: > 94% (ceftazidime, piperacillin and ciprofloxacin), 82-86% (carbapenems, tetracycline), 60-70% (tobramycin, sulbactam, gentamicin, doxycycline), 49% (amikacin), 30% (minocycline, rifampin), 24% (tigecycline), and 3% (colistin). These isolates were, in comparison with those of the first study, more resistant (P < .01) to ceftazidime (99% vs 83%), carbapenems (82-86% vs 43-48%), sulbactam (65% vs 53%) and colistin (3% vs 0%), but more susceptible to aminoglycosides (particularly gentamicin: 70% vs 96% of resistant isolates), tetracycline (83% vs 91%) and rifampicin (30% vs 51%) | ||
| 520 | |a CONCLUSION: There is a high prevalence of A. baumannii resistant to antimicrobials, particularly to carbapenems. The resistance to carbapenems, ceftazidime and sulbactam was significantly higher than that observed for isolates from the GEIH-Ab project 2000. The resistance to aminoglycosides, tetracycline and rifampin, however, was significantly decreased | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Tomás-Carmona, María |e verfasserin |4 aut | |
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| 700 | 0 | |a grupo del proyecto GEIH-REIPI-Ab 2010 |e verfasserin |4 aut | |
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| 700 | 1 | |a Chao, José Carlos Villar |e investigator |4 oth | |
| 700 | 1 | |a Ortega, Belén Padilla |e investigator |4 oth | |
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| 700 | 1 | |a Irure, José Javier García |e investigator |4 oth | |
| 700 | 1 | |a del Arco Jiménez, Alfonso |e investigator |4 oth | |
| 700 | 1 | |a de la Torre Lima, Javier |e investigator |4 oth | |
| 700 | 1 | |a Cardona, Concepción Gimeno |e investigator |4 oth | |
| 700 | 1 | |a Abril, Vicente |e investigator |4 oth | |
| 700 | 1 | |a Pujals, Joseph Vilaró |e investigator |4 oth | |
| 700 | 1 | |a Aguirre, Marian Navarro |e investigator |4 oth | |
| 700 | 1 | |a Alfaro, José Antonio Jiménez |e investigator |4 oth | |
| 700 | 1 | |a Reviejo Jaca, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Casanova, Pilar Marín |e investigator |4 oth | |
| 700 | 1 | |a Guerreo, Francisca |e investigator |4 oth | |
| 700 | 1 | |a Mayoral, Teresa Nebreda |e investigator |4 oth | |
| 700 | 1 | |a Calavia, María José Fernández |e investigator |4 oth | |
| 700 | 1 | |a de Lucas, Esperanza Merino |e investigator |4 oth | |
| 700 | 1 | |a Zorraquino, Alfredo |e investigator |4 oth | |
| 700 | 1 | |a Eseverri, Eugenio Garduño |e investigator |4 oth | |
| 700 | 1 | |a Sánchez, Luis López |e investigator |4 oth | |
| 700 | 1 | |a Gutiérrez, Ana Fleites |e investigator |4 oth | |
| 700 | 1 | |a Guardado, Azucena Rodríguez |e investigator |4 oth | |
| 700 | 1 | |a García-Arenzana Anguera, José María |e investigator |4 oth | |
| 700 | 1 | |a Palmero, Serafín López |e investigator |4 oth | |
| 700 | 1 | |a Maresca, Manuel Rodríguez |e investigator |4 oth | |
| 700 | 1 | |a Garrote, Fernando García |e investigator |4 oth | |
| 700 | 1 | |a Otero, José Varela |e investigator |4 oth | |
| 700 | 1 | |a Verdú, Elisa Vidal |e investigator |4 oth | |
| 700 | 1 | |a López, Fernando Rodríguez |e investigator |4 oth | |
| 700 | 1 | |a Sánchez, Fernanda Pardo |e investigator |4 oth | |
| 700 | 1 | |a Vizoso, E Ferrer |e investigator |4 oth | |
| 700 | 1 | |a Gurgui, Mercé |e investigator |4 oth | |
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| 700 | 1 | |a Igartua, Rafael Ayarza |e investigator |4 oth | |
| 700 | 1 | |a Romero, María Dolores Maciá |e investigator |4 oth | |
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| 700 | 1 | |a Romero, María Isabel Sánchez |e investigator |4 oth | |
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