A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved..
BACKGROUND: Recent experimental evidence suggests that the Rho/Rho-kinase (ROCK) system may play an important role in the pathogenesis of acute coronary syndrome (ACS) but there are little clinical data. This study examined if ROCK activity is increased in patients with acute coronary syndrome and if ROCK activity predicts long-term cardiovascular event.
METHOD: Blood samples were collected from 188 patients within 12h after admission for ACS (53% men; aged 70 ± 13) and from 61 control subject. The main outcome measures were all cause mortality, readmission with ACS or congestive heart failure (CHF) from presentation within around 2 years (mean:14.4 ± 7.2 months; range: 0.5 to 26 months).
RESULTS: ROCK activity increased in ST elevation myocardial infarction (STEMI, n=90) (3.33 ± 0.93), non-STEMI (NSTEMI, n=68) (3.37 ± 1.04) and unstable angina (UA, n=30) (2.53 ± 0.59) groups when compared with disease controls (n=31) (2.06 ± 0.38, all p<0.001) and healthy controls (n=30) (1.54 ± 0.43, all p<0.001). There were 24 deaths, 34 readmissions with ACS and 15 admissions with CHF within 2 years. Patients with a high N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high ROCK activity on admission had a five-fold risk of a cardiovascular event (RR: 5.156; 95% CI: 2.180-12.191) when compared to those with low NT-proBNP and low ROCK activity.
CONCLUSION: ROCK activity was increased in patients with ACS, particularly in those with myocardial infarction. The combined usage of both ROCK activity and NT-proBNP might identify a subset of ACS patients at particularly high risk.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:167 |
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| Enthalten in: |
International journal of cardiology - 167(2013), 6 vom: 10. Sept., Seite 2813-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dong, Ming [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.04.2014 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2012.07.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM220496900 |
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| 100 | 1 | |a Dong, Ming |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome |
| 264 | 1 | |c 2013 | |
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| 500 | |a Date Completed 22.04.2014 | ||
| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Recent experimental evidence suggests that the Rho/Rho-kinase (ROCK) system may play an important role in the pathogenesis of acute coronary syndrome (ACS) but there are little clinical data. This study examined if ROCK activity is increased in patients with acute coronary syndrome and if ROCK activity predicts long-term cardiovascular event | ||
| 520 | |a METHOD: Blood samples were collected from 188 patients within 12h after admission for ACS (53% men; aged 70 ± 13) and from 61 control subject. The main outcome measures were all cause mortality, readmission with ACS or congestive heart failure (CHF) from presentation within around 2 years (mean:14.4 ± 7.2 months; range: 0.5 to 26 months) | ||
| 520 | |a RESULTS: ROCK activity increased in ST elevation myocardial infarction (STEMI, n=90) (3.33 ± 0.93), non-STEMI (NSTEMI, n=68) (3.37 ± 1.04) and unstable angina (UA, n=30) (2.53 ± 0.59) groups when compared with disease controls (n=31) (2.06 ± 0.38, all p<0.001) and healthy controls (n=30) (1.54 ± 0.43, all p<0.001). There were 24 deaths, 34 readmissions with ACS and 15 admissions with CHF within 2 years. Patients with a high N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high ROCK activity on admission had a five-fold risk of a cardiovascular event (RR: 5.156; 95% CI: 2.180-12.191) when compared to those with low NT-proBNP and low ROCK activity | ||
| 520 | |a CONCLUSION: ROCK activity was increased in patients with ACS, particularly in those with myocardial infarction. The combined usage of both ROCK activity and NT-proBNP might identify a subset of ACS patients at particularly high risk | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ACS | |
| 650 | 4 | |a ANOVA | |
| 650 | 4 | |a Acute coronary syndrome | |
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| 650 | 4 | |a CHD | |
| 650 | 4 | |a CHF | |
| 650 | 4 | |a CIHD | |
| 650 | 4 | |a CPK | |
| 650 | 4 | |a CRP | |
| 650 | 4 | |a CVA | |
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| 650 | 4 | |a Estimated Glomerular Filtration Rate | |
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| 650 | 4 | |a Left ventricular ejection fraction | |
| 650 | 4 | |a Low-density lipoprotein cholesterol | |
| 650 | 4 | |a N-terminal pro-B-type natriuretic peptide | |
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| 650 | 4 | |a Non-ST elevation myocardial infarction | |
| 650 | 4 | |a One-way analysis of variance | |
| 650 | 4 | |a PCI | |
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| 650 | 4 | |a Rho kinase | |
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| 700 | 1 | |a Liao, James K |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Bryan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ruijie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Mang |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Cheuk-Man |e verfasserin |4 aut | |
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