CT- versus coregistered FDG-PET/CT-based radiation therapy plans for conformal radiotherapy in colorectal liver metastases : a dosimetric comparison
PURPOSE: Our aim was to compare computed tomography (CT) and coregistered [(18)F]-fluorodeoxyglucose positron emission tomography CT-(FDG-PET/CT) based delineation of gross tumor volume (GTV) in unresectable colorectal liver metastasis (CRLM).
MATERIALS AND METHODS: Fifty-four patients with unresectable CRLM were enrolled but 16 were excluded due to detection of additional hepatic metastases in ten on PET/CT scans, precluding radiotherapy because of transcendent critical organ doses beyond tolerable limits; and of extrahepatic metastases in six. For 38 eligible patients, both CT and PET/CT images were acquired, and two 3D conformal plans were made using the CT and FDG-PET/CT fusion data sets. Radiotherapy plans (RTP) and doses to critical organs were analyzed.
RESULTS: Comparisons between two RTPs revealed need for change in GTV in 31 of 38 analyzable patients (81.6 %). In 25 (65.8 %) patients, GTV was significantly increased, with a median of 33.2 % (p < 0.001), whereas median 12.8 % decrease in six (15.8 %) (p < 0.001). There were no clinically meaningful differences in critical organ doses.
CONCLUSION: Coregistered FDG-PET/CT may improve delineation of GTV and theoretically reduce the likelihood of geographic misses in unresectable CRLM. Additionally, integration of FDG-PET/CT in the initial assessments of CRLM may spare almost one third of patients from potentially futile radical interventions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Japanese journal of radiology - 30(2012), 8 vom: 07. Okt., Seite 628-34 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Parlak, Cem [VerfasserIn] |
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| Links: |
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| Themen: |
0Z5B2CJX4D |
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| Anmerkungen: |
Date Completed 22.05.2013 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11604-012-0101-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM21902734X |
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| 245 | 1 | 0 | |a CT- versus coregistered FDG-PET/CT-based radiation therapy plans for conformal radiotherapy in colorectal liver metastases |b a dosimetric comparison |
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| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: Our aim was to compare computed tomography (CT) and coregistered [(18)F]-fluorodeoxyglucose positron emission tomography CT-(FDG-PET/CT) based delineation of gross tumor volume (GTV) in unresectable colorectal liver metastasis (CRLM) | ||
| 520 | |a MATERIALS AND METHODS: Fifty-four patients with unresectable CRLM were enrolled but 16 were excluded due to detection of additional hepatic metastases in ten on PET/CT scans, precluding radiotherapy because of transcendent critical organ doses beyond tolerable limits; and of extrahepatic metastases in six. For 38 eligible patients, both CT and PET/CT images were acquired, and two 3D conformal plans were made using the CT and FDG-PET/CT fusion data sets. Radiotherapy plans (RTP) and doses to critical organs were analyzed | ||
| 520 | |a RESULTS: Comparisons between two RTPs revealed need for change in GTV in 31 of 38 analyzable patients (81.6 %). In 25 (65.8 %) patients, GTV was significantly increased, with a median of 33.2 % (p < 0.001), whereas median 12.8 % decrease in six (15.8 %) (p < 0.001). There were no clinically meaningful differences in critical organ doses | ||
| 520 | |a CONCLUSION: Coregistered FDG-PET/CT may improve delineation of GTV and theoretically reduce the likelihood of geographic misses in unresectable CRLM. Additionally, integration of FDG-PET/CT in the initial assessments of CRLM may spare almost one third of patients from potentially futile radical interventions | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Reyhan, Mehmet |e verfasserin |4 aut | |
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