Hypermethylation of p16 tumor-suppressor gene in ameloblastic carcinoma, ameloblastoma, and dental follicles
Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved..
PURPOSE: The high rate of p16 gene alterations in malignant neoplasms suggests the important effect of this tumor-suppressor gene mutation on the malignant behavior of tumoral lesions. The present study investigated the possible methylation of the p16 tumor in ameloblastic carcinoma, ameloblastoma, and dental follicles.
MATERIALS AND METHODS: Eighteen samples of ameloblastic carcinoma, ameloblastoma, and dental follicles of mandibular impacted third molar were selected from available documents in the archives of the Department of Oral and Maxillofacial Pathology, Taleghani Hospital and the Department of Oral and Maxillofacial Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. After confirming the initial diagnosis, 6-μm sections were used for DNA extraction. A CpG island methylation of p16 was identified by polymerase chain reaction.
RESULTS: Although CpG methylation of p16 was observed in all ameloblastic carcinoma samples, only 1 ameloblastoma specimen exhibited the mutation. The mutation was not detected in other ameloblastoma specimens or in any dental follicle sample.
CONCLUSIONS: The p16 alteration might play a role in the malignant progression of ameloblastic carcinoma. It is worth mentioning that ameloblastoma can be further differentiated from ameloblastic carcinoma based on molecular observations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
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| Enthalten in: |
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons - 71(2013), 1 vom: 03. Jan., Seite 62-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Khojasteh, Arash [VerfasserIn] |
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| Anmerkungen: |
Date Completed 11.02.2013 Date Revised 10.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.joms.2012.04.033 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM218682689 |
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| 245 | 1 | 0 | |a Hypermethylation of p16 tumor-suppressor gene in ameloblastic carcinoma, ameloblastoma, and dental follicles |
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| 500 | |a Date Completed 11.02.2013 | ||
| 500 | |a Date Revised 10.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: The high rate of p16 gene alterations in malignant neoplasms suggests the important effect of this tumor-suppressor gene mutation on the malignant behavior of tumoral lesions. The present study investigated the possible methylation of the p16 tumor in ameloblastic carcinoma, ameloblastoma, and dental follicles | ||
| 520 | |a MATERIALS AND METHODS: Eighteen samples of ameloblastic carcinoma, ameloblastoma, and dental follicles of mandibular impacted third molar were selected from available documents in the archives of the Department of Oral and Maxillofacial Pathology, Taleghani Hospital and the Department of Oral and Maxillofacial Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. After confirming the initial diagnosis, 6-μm sections were used for DNA extraction. A CpG island methylation of p16 was identified by polymerase chain reaction | ||
| 520 | |a RESULTS: Although CpG methylation of p16 was observed in all ameloblastic carcinoma samples, only 1 ameloblastoma specimen exhibited the mutation. The mutation was not detected in other ameloblastoma specimens or in any dental follicle sample | ||
| 520 | |a CONCLUSIONS: The p16 alteration might play a role in the malignant progression of ameloblastic carcinoma. It is worth mentioning that ameloblastoma can be further differentiated from ameloblastic carcinoma based on molecular observations | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Khodayari, Abbas |e verfasserin |4 aut | |
| 700 | 1 | |a Rahimi, Farzaneh |e verfasserin |4 aut | |
| 700 | 1 | |a Ghaderian, Mohamad Hossain |e verfasserin |4 aut | |
| 700 | 1 | |a Jafarian, Mohamad |e verfasserin |4 aut | |
| 700 | 1 | |a Nayebi, Alireza |e verfasserin |4 aut | |
| 700 | 1 | |a Akbarzadeh Najar, Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Tabatabayipanah, Akram |e verfasserin |4 aut | |
| 700 | 1 | |a Jahangirnia, Alireza |e verfasserin |4 aut | |
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