Monastrol mimic Biginelli dihydropyrimidinone derivatives : synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study
Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC50 values of the synthesized compounds against the proliferation of human hepatocellular carcinoma and human epithelial carcinoma cell lines were determined through MTT assay. Molecular docking study gave a clear insight into the structural activity relationship of the compounds in comparison with monastrol.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
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| Enthalten in: |
Organic and medicinal chemistry letters - 2(2012), 1 vom: 12. Juni, Seite 23 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Soumyanarayanan, Uttara [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 12.12.2012 Date Revised 21.10.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1186/2191-2858-2-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM218561970 |
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| 100 | 1 | |a Soumyanarayanan, Uttara |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Monastrol mimic Biginelli dihydropyrimidinone derivatives |b synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC50 values of the synthesized compounds against the proliferation of human hepatocellular carcinoma and human epithelial carcinoma cell lines were determined through MTT assay. Molecular docking study gave a clear insight into the structural activity relationship of the compounds in comparison with monastrol | ||
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| 700 | 1 | |a Mathew, Jesil A |e verfasserin |4 aut | |
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