Can we predict the severity of pulmonary hypertension in patients with scleroderma?
Copyright © 2011 Elsevier España, S.L. All rights reserved..
OBJECTIVES: To describe the clinical-biological characteristics of patients with scleroderma (SSc) and pulmonary artery hypertension (PAH). To establish the relationship between pulmonary functional tests (PFT), Doppler echocardiography (ECHO) and the severity of the PAH.
MATERIAL AND METHODS: Retrospective study of patients with scleroderma treated at a tertiary center. All participants received a protocol study, which included a complete analysis and additional tests: Doppler Echocardiography and pulmonary functional tests (PFT) with carbon monoxide diffusing capacity (DLCO).
RESULTS: Overall, 331 patients were treated, including 68 (20.5%) with PAH. The limited subtype of Scleroderma was the most prevalent. The Person's correlation coefficient was used for the following variables: FVC-sPAP, FVC/DLCO-sPAP, DLCO-sPAP and TRV-sPAP, showed a significant moderate linear association in the relationship DLCO-sPAP and TRV-sPAP. 29 deaths occurred, with 12 of them related to PAH. The median time between the PAH diagnosis and death was 1.8 years.
CONCLUSIONS: The decrease in DLCO and the increase in TRV are negative predictor factor of PAH which, at the same time, means a worsening prognosis for patients with Scleroderma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Reumatologia clinica - 8(2012), 5 vom: 09. Sept., Seite 259-62 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Acosta Colmán, María Isabel [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 25.02.2013 Date Revised 09.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM218286503 |
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| 100 | 1 | |a Acosta Colmán, María Isabel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Can we predict the severity of pulmonary hypertension in patients with scleroderma? |
| 264 | 1 | |c 2012 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 25.02.2013 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2011 Elsevier España, S.L. All rights reserved. | ||
| 520 | |a OBJECTIVES: To describe the clinical-biological characteristics of patients with scleroderma (SSc) and pulmonary artery hypertension (PAH). To establish the relationship between pulmonary functional tests (PFT), Doppler echocardiography (ECHO) and the severity of the PAH | ||
| 520 | |a MATERIAL AND METHODS: Retrospective study of patients with scleroderma treated at a tertiary center. All participants received a protocol study, which included a complete analysis and additional tests: Doppler Echocardiography and pulmonary functional tests (PFT) with carbon monoxide diffusing capacity (DLCO) | ||
| 520 | |a RESULTS: Overall, 331 patients were treated, including 68 (20.5%) with PAH. The limited subtype of Scleroderma was the most prevalent. The Person's correlation coefficient was used for the following variables: FVC-sPAP, FVC/DLCO-sPAP, DLCO-sPAP and TRV-sPAP, showed a significant moderate linear association in the relationship DLCO-sPAP and TRV-sPAP. 29 deaths occurred, with 12 of them related to PAH. The median time between the PAH diagnosis and death was 1.8 years | ||
| 520 | |a CONCLUSIONS: The decrease in DLCO and the increase in TRV are negative predictor factor of PAH which, at the same time, means a worsening prognosis for patients with Scleroderma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Carbon Monoxide |2 NLM | |
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| 700 | 1 | |a Avila Pedretti, Gabriela |e verfasserin |4 aut | |
| 700 | 1 | |a Acosta, María Eugenia |e verfasserin |4 aut | |
| 700 | 1 | |a Simeón Aznar, Carmen Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Fonollosa Plá, Vicent |e verfasserin |4 aut | |
| 700 | 1 | |a Villardel Torrés, Miquel |e verfasserin |4 aut | |
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