Diversin, from Ferula diversivittata protects human lymphocytes against oxidative stress induced by H₂O₂
In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay. Isolated lymphocytes from healthy volunteers' blood samples were incubated with diversin (10, 25, 50, 100, 200 and 400 µM) alone, or in the presence of H2O2 (25 µM). DNA break was measured based on the %tail DNA and compared with different concentrations of curcumin (10, 25 and 50 µM) as the positive control. It was shown that all concentrations of diversin significantly reduce DNA damage caused by H2O2.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Natural product research - 27(2013), 11 vom: 26., Seite 1016-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zarei, Hassan [VerfasserIn] |
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| Links: |
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| Themen: |
BBX060AN9V |
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| Anmerkungen: |
Date Completed 15.01.2014 Date Revised 19.06.2013 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14786419.2012.688053 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM217994806 |
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| 520 | |a In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay. Isolated lymphocytes from healthy volunteers' blood samples were incubated with diversin (10, 25, 50, 100, 200 and 400 µM) alone, or in the presence of H2O2 (25 µM). DNA break was measured based on the %tail DNA and compared with different concentrations of curcumin (10, 25 and 50 µM) as the positive control. It was shown that all concentrations of diversin significantly reduce DNA damage caused by H2O2 | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Mosaffa, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Iranshahi, Mehrdad |e verfasserin |4 aut | |
| 700 | 1 | |a Behravan, Javad |e verfasserin |4 aut | |
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