The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility
The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in vivo, we have used Cre/loxP technology to generate mice deficient for Tsc22d3-2. Male knockout mice were viable but surprisingly did not show any major deficiencies in immunological processes or inflammatory responses. Tsc22d3-2 knockout mice adapted to a sodium-deprived diet and to water deprivation conditions but developed a subtle deficiency in renal sodium and water handling. Moreover, the affected animals developed a mild metabolic phenotype evident by a reduction in weight from 6 months of age, mild hyperinsulinemia, and resistance to a high-fat diet. Tsc22d3-2-deficient males were infertile and exhibited severe testis dysplasia from postnatal d 10 onward with increases in apoptotic cells within seminiferous tubules, an increased number of Leydig cells, and significantly elevated FSH and testosterone levels. Thus, our analysis of the Tsc22d3-2-deficient mice demonstrated a previously uncharacterized function of glucocorticoid-induced leucine zipper protein in testis development.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Molecular endocrinology (Baltimore, Md.) - 26(2012), 6 vom: 29. Juni, Seite 1000-13 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suarez, Philippe Emmanuel [VerfasserIn] |
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| Links: |
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| Themen: |
7S5I7G3JQL |
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| Anmerkungen: |
Date Completed 20.09.2012 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1210/me.2011-1249 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM21750728X |
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| 100 | 1 | |a Suarez, Philippe Emmanuel |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility |
| 264 | 1 | |c 2012 | |
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| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in vivo, we have used Cre/loxP technology to generate mice deficient for Tsc22d3-2. Male knockout mice were viable but surprisingly did not show any major deficiencies in immunological processes or inflammatory responses. Tsc22d3-2 knockout mice adapted to a sodium-deprived diet and to water deprivation conditions but developed a subtle deficiency in renal sodium and water handling. Moreover, the affected animals developed a mild metabolic phenotype evident by a reduction in weight from 6 months of age, mild hyperinsulinemia, and resistance to a high-fat diet. Tsc22d3-2-deficient males were infertile and exhibited severe testis dysplasia from postnatal d 10 onward with increases in apoptotic cells within seminiferous tubules, an increased number of Leydig cells, and significantly elevated FSH and testosterone levels. Thus, our analysis of the Tsc22d3-2-deficient mice demonstrated a previously uncharacterized function of glucocorticoid-induced leucine zipper protein in testis development | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a Dsip1 protein, mouse |2 NLM | |
| 650 | 7 | |a Immunologic Factors |2 NLM | |
| 650 | 7 | |a Lipopolysaccharides |2 NLM | |
| 650 | 7 | |a Protein Isoforms |2 NLM | |
| 650 | 7 | |a Transcription Factors |2 NLM | |
| 650 | 7 | |a Dexamethasone |2 NLM | |
| 650 | 7 | |a 7S5I7G3JQL |2 NLM | |
| 700 | 1 | |a Rodriguez, Elena Gonzalez |e verfasserin |4 aut | |
| 700 | 1 | |a Soundararajan, Rama |e verfasserin |4 aut | |
| 700 | 1 | |a Mérillat, Anne-Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Stehle, Jean-Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Rotman, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Roger, Thierry |e verfasserin |4 aut | |
| 700 | 1 | |a Voirol, Marie-Jeanne |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Gross, Olaf |e verfasserin |4 aut | |
| 700 | 1 | |a Pétrilli, Virginie |e verfasserin |4 aut | |
| 700 | 1 | |a Nadra, Karim |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Beermann, Friedrich |e verfasserin |4 aut | |
| 700 | 1 | |a Pralong, François Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Maillard, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Pearce, David |e verfasserin |4 aut | |
| 700 | 1 | |a Chrast, Roman |e verfasserin |4 aut | |
| 700 | 1 | |a Rossier, Bernard Claude |e verfasserin |4 aut | |
| 700 | 1 | |a Hummler, Edith |e verfasserin |4 aut | |
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