IgM enriched immunoglobulins as a therapy for sepsis and autoimmune diseases
The importance of natural autoreactive antibodies of the immunogtobulin M (IgM) isotype, raised the issue of the innate immune response being immunoregulatory. These antibodies have low affinity and a wide range of specificity, thus acting as protective autoantibodies. Bearing this in mind, many have proposed the therapeutics potential of IgM enriched intravenous immunoglobulin (IVIg) in sepsis and in autoimmune diseases. We will summarize the emerging knowledge of these natural autoreactive IgM antibodies, their role and mechanisms of action in the above mentioned diseases.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:151 |
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| Enthalten in: |
Harefuah - 151(2012), 3 vom: 01. März, Seite 171-4, 188 |
| Sprache: |
Hebräisch |
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| Beteiligte Personen: |
Yehudai, Dana [VerfasserIn] |
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| Themen: |
Autoantibodies |
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| Anmerkungen: |
Date Completed 03.05.2012 Date Revised 23.04.2012 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM217156304 |
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| 245 | 1 | 0 | |a IgM enriched immunoglobulins as a therapy for sepsis and autoimmune diseases |
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| 500 | |a Date Revised 23.04.2012 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The importance of natural autoreactive antibodies of the immunogtobulin M (IgM) isotype, raised the issue of the innate immune response being immunoregulatory. These antibodies have low affinity and a wide range of specificity, thus acting as protective autoantibodies. Bearing this in mind, many have proposed the therapeutics potential of IgM enriched intravenous immunoglobulin (IVIg) in sepsis and in autoimmune diseases. We will summarize the emerging knowledge of these natural autoreactive IgM antibodies, their role and mechanisms of action in the above mentioned diseases | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
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| 650 | 7 | |a Immunoglobulins, Intravenous |2 NLM | |
| 650 | 7 | |a Immunologic Factors |2 NLM | |
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