Differences in the causes of death of HIV-positive patients in a cohort study by data sources and coding algorithms
OBJECTIVES: To compare causes of death (CoDs) from two independent sources: National Basic Death File (NBDF) and deaths reported to the Spanish HIV Research cohort [Cohort de adultos con infección por VIH de la Red de Investigación en SIDA CoRIS)] and compare the two coding algorithms: International Classification of Diseases, 10th revision (ICD-10) and revised version of Coding Causes of Death in HIV (revised CoDe).
METHODS: Between 2004 and 2008, CoDs were obtained from the cohort records (free text, multiple causes) and also from NBDF (ICD-10). CoDs from CoRIS were coded according to ICD-10 and revised CoDe by a panel. Deaths were compared by 13 disease groups: HIV/AIDS, liver diseases, malignancies, infections, cardiovascular, blood disorders, pulmonary, central nervous system, drug use, external, suicide, other causes and ill defined.
RESULTS: There were 160 deaths. Concordance for the 13 groups was observed in 111 (69%) cases for the two sources and in 115 (72%) cases for the two coding algorithms. According to revised CoDe, the commonest CoDs were HIV/AIDS (53%), non-AIDS malignancies (11%) and liver related (9%), these percentages were similar, 57, 10 and 8%, respectively, for NBDF (coded as ICD-10). When using ICD-10 to code deaths in CoRIS, wherein HIV infection was known in everyone, the proportion of non-AIDS malignancies was 13%, liver-related accounted for 3%, while HIV/AIDS reached 70% due to liver-related, infections and ill-defined causes being coded as HIV/AIDS.
CONCLUSION: There is substantial variation in CoDs in HIV-infected persons according to sources and algorithms. ICD-10 in patients known to be HIV-positive overestimates HIV/AIDS-related deaths at the expense of underestimating liver-related diseases, infections and ill defined causes. CoDe seems as the best option for cohort studies.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
|---|---|
| Enthalten in: |
AIDS (London, England) - 26(2012), 14 vom: 10. Sept., Seite 1829-34 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hernando, Victoria [VerfasserIn] |
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| Themen: |
Comparative Study |
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| Anmerkungen: |
Date Completed 16.01.2013 Date Revised 10.03.2022 published: Print CommentIn: AIDS. 2012 Sep 10;26(14):1835-6. - PMID 22954757 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM216133483 |
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| 041 | |a eng | ||
| 100 | 1 | |a Hernando, Victoria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Differences in the causes of death of HIV-positive patients in a cohort study by data sources and coding algorithms |
| 264 | 1 | |c 2012 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 16.01.2013 | ||
| 500 | |a Date Revised 10.03.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: AIDS. 2012 Sep 10;26(14):1835-6. - PMID 22954757 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To compare causes of death (CoDs) from two independent sources: National Basic Death File (NBDF) and deaths reported to the Spanish HIV Research cohort [Cohort de adultos con infección por VIH de la Red de Investigación en SIDA CoRIS)] and compare the two coding algorithms: International Classification of Diseases, 10th revision (ICD-10) and revised version of Coding Causes of Death in HIV (revised CoDe) | ||
| 520 | |a METHODS: Between 2004 and 2008, CoDs were obtained from the cohort records (free text, multiple causes) and also from NBDF (ICD-10). CoDs from CoRIS were coded according to ICD-10 and revised CoDe by a panel. Deaths were compared by 13 disease groups: HIV/AIDS, liver diseases, malignancies, infections, cardiovascular, blood disorders, pulmonary, central nervous system, drug use, external, suicide, other causes and ill defined | ||
| 520 | |a RESULTS: There were 160 deaths. Concordance for the 13 groups was observed in 111 (69%) cases for the two sources and in 115 (72%) cases for the two coding algorithms. According to revised CoDe, the commonest CoDs were HIV/AIDS (53%), non-AIDS malignancies (11%) and liver related (9%), these percentages were similar, 57, 10 and 8%, respectively, for NBDF (coded as ICD-10). When using ICD-10 to code deaths in CoRIS, wherein HIV infection was known in everyone, the proportion of non-AIDS malignancies was 13%, liver-related accounted for 3%, while HIV/AIDS reached 70% due to liver-related, infections and ill-defined causes being coded as HIV/AIDS | ||
| 520 | |a CONCLUSION: There is substantial variation in CoDs in HIV-infected persons according to sources and algorithms. ICD-10 in patients known to be HIV-positive overestimates HIV/AIDS-related deaths at the expense of underestimating liver-related diseases, infections and ill defined causes. CoDe seems as the best option for cohort studies | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Sobrino-Vegas, Paz |e verfasserin |4 aut | |
| 700 | 1 | |a Burriel, M Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Berenguer, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Navarro, Gemma |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Reparaz, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, M Angeles |e verfasserin |4 aut | |
| 700 | 1 | |a Antela, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Gutiérrez, Félix |e verfasserin |4 aut | |
| 700 | 1 | |a del Amo, Julia |e verfasserin |4 aut | |
| 700 | 0 | |a CoRIS cohort |e verfasserin |4 aut | |
| 700 | 1 | |a Berenguer, Juan |e investigator |4 oth | |
| 700 | 1 | |a del Amo, Julia |e investigator |4 oth | |
| 700 | 1 | |a García, Federico |e investigator |4 oth | |
| 700 | 1 | |a Gutiérrez, Félix |e investigator |4 oth | |
| 700 | 1 | |a Labarga, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Moreno, Santiago |e investigator |4 oth | |
| 700 | 1 | |a Muñoz, María ángeles |e investigator |4 oth | |
| 700 | 1 | |a Murillo, Ana Maria Caro |e investigator |4 oth | |
| 700 | 1 | |a Vegas, Paz Sobrino |e investigator |4 oth | |
| 700 | 1 | |a Pérez-Cachafeiro, Santiago |e investigator |4 oth | |
| 700 | 1 | |a Sebastián, Victoria Hernando |e investigator |4 oth | |
| 700 | 1 | |a Ferreras, Belén Alejos |e investigator |4 oth | |
| 700 | 1 | |a del Arco, Débora álvarez |e investigator |4 oth | |
| 700 | 1 | |a Corella, Monge |e investigator |4 oth | |
| 700 | 1 | |a Vera, Inma Jarrín |e investigator |4 oth | |
| 700 | 1 | |a Sebastián, Victoria Hernando |e investigator |4 oth | |
| 700 | 1 | |a Vegas, Paz Sobrino |e investigator |4 oth | |
| 700 | 1 | |a Burriel, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Muga, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Gutiérrez, Félix |e investigator |4 oth | |
| 700 | 1 | |a Moreno, Santiago |e investigator |4 oth | |
| 700 | 1 | |a del Amo, Julia |e investigator |4 oth | |
| 700 | 1 | |a Muñoz-Fernández, M ángeles |e investigator |4 oth | |
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| 700 | 1 | |a Rico, Coral Gómez |e investigator |4 oth | |
| 700 | 1 | |a Gallego, Jorge |e investigator |4 oth | |
| 700 | 1 | |a Torre, Almudena García |e investigator |4 oth | |
| 700 | 1 | |a Sogorb, Joaquín Portilla |e investigator |4 oth | |
| 700 | 1 | |a de Lucas, Esperanza Merino |e investigator |4 oth | |
| 700 | 1 | |a Bañuls, Sergio Reus |e investigator |4 oth | |
| 700 | 1 | |a Martínez, Vicente Boix |e investigator |4 oth | |
| 700 | 1 | |a Oncina, Livia Giner |e investigator |4 oth | |
| 700 | 1 | |a Gadea, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Tamarit, Irene Portilla |e investigator |4 oth | |
| 700 | 1 | |a Toledo, Patricia Arcaina |e investigator |4 oth | |
| 700 | 1 | |a Sirvent, Juan Luis Gómez |e investigator |4 oth | |
| 700 | 1 | |a Fortúnez, Patricia Rodríguez |e investigator |4 oth | |
| 700 | 1 | |a Valls, María Remedios Alemán |e investigator |4 oth | |
| 700 | 1 | |a Lirola, Ana María López |e investigator |4 oth | |
| 700 | 1 | |a Hernández, María Inmaculada Hernández |e investigator |4 oth | |
| 700 | 1 | |a Díaz-Flores, Felicitas |e investigator |4 oth | |
| 700 | 1 | |a Soriano, Vicente |e investigator |4 oth | |
| 700 | 1 | |a Labarga, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Barreiro, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Castañares, Carol |e investigator |4 oth | |
| 700 | 1 | |a Rivas, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Ruiz, Andrés |e investigator |4 oth | |
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| 700 | 1 | |a Valle, Eulalia |e investigator |4 oth | |
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| 700 | 1 | |a Zamora, Laura |e investigator |4 oth | |
| 700 | 1 | |a Pérez, Iñaki |e investigator |4 oth | |
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| 700 | 1 | |a Iribarren, José Antonio |e investigator |4 oth | |
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| 700 | 1 | |a Cuellar, Isabel Gutiérrez |e investigator |4 oth | |
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