Week 96 efficacy, virology and safety of darunavir/r versus lopinavir/r in treatment-experienced patients in TITAN
Long-term potent activity of antiretrovirals is essential for HIV-1-infected, treatment-experienced patients. TITAN (TMC114/r In Treatment-experienced pAtients Naive to lopinavir) compared Week-96 efficacy and safety of darunavir/ritonavir (DRV/r) versus lopinavir/ritonavir (LPV/r). Treatment-experienced, LPV-naive, HIV-1-infected patients were randomised to DRV/r 600/100 mg bid or LPV/r 400/100 mg bid plus optimised background regimen (≥ 2 NRTIs/NNRTIs). 595 patients were enrolled (mean baseline HIV-1 RNA: 4.30 log10 copies/mL; median CD4 count: 232 cells/mm3). At Week 96, more DRV/r than LPV/r patients achieved HIV-1 RNA < 400 copies/mL (66.8% versus 58.9% [intent-to-treat (ITT)/time-to-loss of virological response (TLOVR)], estimated difference 8.7%, 95% confidence interval [CI]: 0.7-16.7), demonstrating the primary endpoint of non-inferiority of DRV/r (p < 0.001); the difference in response was statistically significant (p = 0.034). For the secondary efficacy parameter (HIV-1 RNA < 50 copies/mL) at Week 96, response to DRV/r was 60.4% versus 55.2% for LPV/r (ITT-TLOVR), estimated difference 5.8%, 95% CI: -2.3-13.9. Virological failure (VF; HIV-1 RNA > 400 copies/mL) with DRV/r (13.8%) was nearly half that with LPV/r (25.6%). Discontinuations due to adverse events were 8.1% for both DRV/r and LPV/r. Treatment-related grade 2-4 diarrhoea was 8.1% (DRV/r) versus 15.2% (LPV/r). Increases in triglycerides and total cholesterol were less pronounced with DRV/r. At 96 weeks, noninferiority (HIV-1 RNA < 400 copies/mL) of DRV/r over LPV/r was maintained; the difference in response was statistically significant. VF rate and treatment-related grade 2-4 diarrhoea were lower with DRV/r versus LPV/r.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2012 |
---|---|
Erschienen: |
2012 |
Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
---|---|
Enthalten in: |
Current HIV research - 10(2012), 2 vom: 02. März, Seite 171-81 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Bánhegyi, Dénes [VerfasserIn] |
---|
Anmerkungen: |
Date Completed 24.05.2012 Date Revised 12.11.2019 published: Print ClinicalTrials.gov: NCT00110877 Citation Status MEDLINE |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
NLM215462637 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM215462637 | ||
003 | DE-627 | ||
005 | 20231224025601.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2012 xx |||||o 00| ||eng c | ||
028 | 5 | 2 | |a pubmed24n0718.xml |
035 | |a (DE-627)NLM215462637 | ||
035 | |a (NLM)22339125 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Bánhegyi, Dénes |e verfasserin |4 aut | |
245 | 1 | 0 | |a Week 96 efficacy, virology and safety of darunavir/r versus lopinavir/r in treatment-experienced patients in TITAN |
264 | 1 | |c 2012 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 24.05.2012 | ||
500 | |a Date Revised 12.11.2019 | ||
500 | |a published: Print | ||
500 | |a ClinicalTrials.gov: NCT00110877 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Long-term potent activity of antiretrovirals is essential for HIV-1-infected, treatment-experienced patients. TITAN (TMC114/r In Treatment-experienced pAtients Naive to lopinavir) compared Week-96 efficacy and safety of darunavir/ritonavir (DRV/r) versus lopinavir/ritonavir (LPV/r). Treatment-experienced, LPV-naive, HIV-1-infected patients were randomised to DRV/r 600/100 mg bid or LPV/r 400/100 mg bid plus optimised background regimen (≥ 2 NRTIs/NNRTIs). 595 patients were enrolled (mean baseline HIV-1 RNA: 4.30 log10 copies/mL; median CD4 count: 232 cells/mm3). At Week 96, more DRV/r than LPV/r patients achieved HIV-1 RNA < 400 copies/mL (66.8% versus 58.9% [intent-to-treat (ITT)/time-to-loss of virological response (TLOVR)], estimated difference 8.7%, 95% confidence interval [CI]: 0.7-16.7), demonstrating the primary endpoint of non-inferiority of DRV/r (p < 0.001); the difference in response was statistically significant (p = 0.034). For the secondary efficacy parameter (HIV-1 RNA < 50 copies/mL) at Week 96, response to DRV/r was 60.4% versus 55.2% for LPV/r (ITT-TLOVR), estimated difference 5.8%, 95% CI: -2.3-13.9. Virological failure (VF; HIV-1 RNA > 400 copies/mL) with DRV/r (13.8%) was nearly half that with LPV/r (25.6%). Discontinuations due to adverse events were 8.1% for both DRV/r and LPV/r. Treatment-related grade 2-4 diarrhoea was 8.1% (DRV/r) versus 15.2% (LPV/r). Increases in triglycerides and total cholesterol were less pronounced with DRV/r. At 96 weeks, noninferiority (HIV-1 RNA < 400 copies/mL) of DRV/r over LPV/r was maintained; the difference in response was statistically significant. VF rate and treatment-related grade 2-4 diarrhoea were lower with DRV/r versus LPV/r | ||
650 | 4 | |a Clinical Trial, Phase III | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Randomized Controlled Trial | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 7 | |a HIV Protease Inhibitors |2 NLM | |
650 | 7 | |a RNA, Viral |2 NLM | |
650 | 7 | |a Sulfonamides |2 NLM | |
650 | 7 | |a Lopinavir |2 NLM | |
650 | 7 | |a 2494G1JF75 |2 NLM | |
650 | 7 | |a Ritonavir |2 NLM | |
650 | 7 | |a O3J8G9O825 |2 NLM | |
650 | 7 | |a Darunavir |2 NLM | |
650 | 7 | |a YO603Y8113 |2 NLM | |
700 | 1 | |a Katlama, Christine |e verfasserin |4 aut | |
700 | 1 | |a da Cunha, Clóvis Arns |e verfasserin |4 aut | |
700 | 1 | |a Schneider, Stefan |e verfasserin |4 aut | |
700 | 1 | |a Rachlis, Anita |e verfasserin |4 aut | |
700 | 1 | |a Workman, Cassy |e verfasserin |4 aut | |
700 | 1 | |a De Meyer, Sandra |e verfasserin |4 aut | |
700 | 1 | |a Vandevoorde, Ann |e verfasserin |4 aut | |
700 | 1 | |a Van De Casteele, Tom |e verfasserin |4 aut | |
700 | 1 | |a Tomaka, Frank |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Current HIV research |d 2003 |g 10(2012), 2 vom: 02. März, Seite 171-81 |w (DE-627)NLM147412226 |x 1873-4251 |7 nnns |
773 | 1 | 8 | |g volume:10 |g year:2012 |g number:2 |g day:02 |g month:03 |g pages:171-81 |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 10 |j 2012 |e 2 |b 02 |c 03 |h 171-81 |