Suppression of progenitor differentiation requires the long noncoding RNA ANCR
Long noncoding RNAs (lncRNAs) regulate diverse processes, yet a potential role for lncRNAs in maintaining the undifferentiated state in somatic tissue progenitor cells remains uncharacterized. We used transcriptome sequencing and tiling arrays to compare lncRNA expression in epidermal progenitor populations versus differentiating cells. We identified ANCR (anti-differentiation ncRNA) as an 855-base-pair lncRNA down-regulated during differentiation. Depleting ANCR in progenitor-containing populations, without any other stimuli, led to rapid differentiation gene induction. In epidermis, ANCR loss abolished the normal exclusion of differentiation from the progenitor-containing compartment. The ANCR lncRNA is thus required to enforce the undifferentiated cell state within epidermis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Genes & development - 26(2012), 4 vom: 15. Feb., Seite 338-43 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kretz, Markus [VerfasserIn] |
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| Links: |
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| Themen: |
ANCR long noncoding RNA, human |
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| Anmerkungen: |
Date Completed 02.04.2012 Date Revised 20.11.2023 published: Print-Electronic GEO: GSE34767 Citation Status MEDLINE |
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| doi: |
10.1101/gad.182121.111 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM215113233 |
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| 245 | 1 | 0 | |a Suppression of progenitor differentiation requires the long noncoding RNA ANCR |
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| 500 | |a Date Revised 20.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a GEO: GSE34767 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Long noncoding RNAs (lncRNAs) regulate diverse processes, yet a potential role for lncRNAs in maintaining the undifferentiated state in somatic tissue progenitor cells remains uncharacterized. We used transcriptome sequencing and tiling arrays to compare lncRNA expression in epidermal progenitor populations versus differentiating cells. We identified ANCR (anti-differentiation ncRNA) as an 855-base-pair lncRNA down-regulated during differentiation. Depleting ANCR in progenitor-containing populations, without any other stimuli, led to rapid differentiation gene induction. In epidermis, ANCR loss abolished the normal exclusion of differentiation from the progenitor-containing compartment. The ANCR lncRNA is thus required to enforce the undifferentiated cell state within epidermis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 7 | |a ANCR long noncoding RNA, human |2 NLM | |
| 650 | 7 | |a RNA, Long Noncoding |2 NLM | |
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| 700 | 1 | |a Webster, Dan E |e verfasserin |4 aut | |
| 700 | 1 | |a Flockhart, Ross J |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Carolyn S |e verfasserin |4 aut | |
| 700 | 1 | |a Zehnder, Ashley |e verfasserin |4 aut | |
| 700 | 1 | |a Lopez-Pajares, Vanessa |e verfasserin |4 aut | |
| 700 | 1 | |a Qu, Kun |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Grace X Y |e verfasserin |4 aut | |
| 700 | 1 | |a Chow, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Grace E |e verfasserin |4 aut | |
| 700 | 1 | |a Rinn, John L |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Howard Y |e verfasserin |4 aut | |
| 700 | 1 | |a Siprashvili, Zurab |e verfasserin |4 aut | |
| 700 | 1 | |a Khavari, Paul A |e verfasserin |4 aut | |
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