A proteomic analysis of pediatric seizure cases associated with astrocytic inclusions
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy..
Cerebral hyaline astrocytic inclusions have been observed in a subset of patients with early onset epilepsy, brain structural anomalies, and developmental delay, which indicates that it may represent a unique clinicopathologic entity. To further characterize this condition we use proteomics to investigate differentially expressed proteins in epileptic brain tissue from three pediatric epileptic patients with cerebral hyaline astrocytic inclusions, ranging in age from 5-13 years, and compare to brain tissue from two normal controls. Catalase and carbonic anhydrase I both exhibited increased expression in epileptic brain tissue compared to controls. These findings were confirmed by Western blot analysis. Furthermore, both proteins were localized to astrocytes and in epileptic brain were located within the cerebral hyaline astrocytic inclusions, suggesting a potential role in the generation of this pathologic feature of early onset epilepsy with cerebral hyaline astrocytic inclusions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Epilepsia - 53(2012), 3 vom: 16. März, Seite e50-4 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Visanji, Naomi P [VerfasserIn] |
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| Links: |
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| Themen: |
Carbonic Anhydrases |
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| Anmerkungen: |
Date Completed 23.04.2012 Date Revised 29.02.2012 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/j.1528-1167.2011.03369.x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM214328457 |
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| 245 | 1 | 2 | |a A proteomic analysis of pediatric seizure cases associated with astrocytic inclusions |
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| 520 | |a Wiley Periodicals, Inc. © 2012 International League Against Epilepsy. | ||
| 520 | |a Cerebral hyaline astrocytic inclusions have been observed in a subset of patients with early onset epilepsy, brain structural anomalies, and developmental delay, which indicates that it may represent a unique clinicopathologic entity. To further characterize this condition we use proteomics to investigate differentially expressed proteins in epileptic brain tissue from three pediatric epileptic patients with cerebral hyaline astrocytic inclusions, ranging in age from 5-13 years, and compare to brain tissue from two normal controls. Catalase and carbonic anhydrase I both exhibited increased expression in epileptic brain tissue compared to controls. These findings were confirmed by Western blot analysis. Furthermore, both proteins were localized to astrocytes and in epileptic brain were located within the cerebral hyaline astrocytic inclusions, suggesting a potential role in the generation of this pathologic feature of early onset epilepsy with cerebral hyaline astrocytic inclusions | ||
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| 700 | 1 | |a Wong, Janice C |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Simon X |e verfasserin |4 aut | |
| 700 | 1 | |a Cappel, Blair |e verfasserin |4 aut | |
| 700 | 1 | |a Kleinschmidt-Demasters, Bette K |e verfasserin |4 aut | |
| 700 | 1 | |a Handler, Michael H |e verfasserin |4 aut | |
| 700 | 1 | |a Ochi, Ayako |e verfasserin |4 aut | |
| 700 | 1 | |a Otsubo, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Rutka, James T |e verfasserin |4 aut | |
| 700 | 1 | |a Go, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Shelly |e verfasserin |4 aut | |
| 700 | 1 | |a Vinters, Harry V |e verfasserin |4 aut | |
| 700 | 1 | |a Hawkins, Cynthia E |e verfasserin |4 aut | |
| 700 | 1 | |a Desouza, Leroi V |e verfasserin |4 aut | |
| 700 | 1 | |a Siu, K W Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Hazrati, Lili-Naz |e verfasserin |4 aut | |
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