A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus
A primary function of B lymphocytes is immunoglobulin production; however, the therapeutic benefit of B cell depletion in autoimmune diseases previously thought to be T cell mediated suggests that some B cells fulfill other roles in autoimmunity. We examined the recently identified human B1 cell population for T cell stimulatory activity. We found two kinds of B1 cells that are distinguished by multiple surface markers and distinct transcriptomic profiles. In both umbilical cord and adult peripheral blood, a CD11b(+) subset constitutes ~1 out of every 8-10 B1 cells, whereas a CD11b(-) subset constitutes the remaining B1 cells. These B1 cell populations differ functionally. CD11b(-) B1 cells spontaneously secrete much more IgM than CD11b(+) B1 cells. In contrast, CD11b(+) B1 cells express more CD86, and more efficiently stimulate allogeneic CD4(+) T cell expansion, than CD11b(-) B1 cells. The frequency of these CD11b(+) B1 cells is markedly elevated in lupus patients. CD11b(+) B1 cells in lupus patients express more CD86 and have increased T cell-stimulating activity in disease. This work distinguishes a novel, T cell-interacting B1 cell population whose abundance and activity may be a reflection of, and a therapeutic target in, autoimmune disease.
| Errataetall: |
CommentIn: J Exp Med. 2012 Mar 12;209(3):433-4. - PMID 22412175 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:208 |
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| Enthalten in: |
The Journal of experimental medicine - 208(2011), 13 vom: 19. Dez., Seite 2591-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Griffin, Daniel O [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.02.2012 Date Revised 21.10.2021 published: Print-Electronic GEO: GSE29717 CommentIn: J Exp Med. 2012 Mar 12;209(3):433-4. - PMID 22412175 Citation Status MEDLINE |
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| doi: |
10.1084/jem.20110978 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM213295482 |
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| 245 | 1 | 2 | |a A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus |
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| 500 | |a CommentIn: J Exp Med. 2012 Mar 12;209(3):433-4. - PMID 22412175 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A primary function of B lymphocytes is immunoglobulin production; however, the therapeutic benefit of B cell depletion in autoimmune diseases previously thought to be T cell mediated suggests that some B cells fulfill other roles in autoimmunity. We examined the recently identified human B1 cell population for T cell stimulatory activity. We found two kinds of B1 cells that are distinguished by multiple surface markers and distinct transcriptomic profiles. In both umbilical cord and adult peripheral blood, a CD11b(+) subset constitutes ~1 out of every 8-10 B1 cells, whereas a CD11b(-) subset constitutes the remaining B1 cells. These B1 cell populations differ functionally. CD11b(-) B1 cells spontaneously secrete much more IgM than CD11b(+) B1 cells. In contrast, CD11b(+) B1 cells express more CD86, and more efficiently stimulate allogeneic CD4(+) T cell expansion, than CD11b(-) B1 cells. The frequency of these CD11b(+) B1 cells is markedly elevated in lupus patients. CD11b(+) B1 cells in lupus patients express more CD86 and have increased T cell-stimulating activity in disease. This work distinguishes a novel, T cell-interacting B1 cell population whose abundance and activity may be a reflection of, and a therapeutic target in, autoimmune disease | ||
| 650 | 4 | |a Clinical Trial | |
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