Sclerostin is overexpressed by plasma cells from multiple myeloma patients
© 2011 New York Academy of Sciences..
Sclerostin, an osteocyte-expressed negative regulator of bone formation, is one of the inhibitors of Wnt signaling that is a critical pathway in the correct process of osteoblast differentiation. It has been demonstrated that Wnt signaling through the secretion of Wnt inhibitors, such as DKK1, sFRP-2, and sFRP-3, plays a key role in the decreased osteoblast activity associated with multiple myeloma (MM) bone disease. We provide evidence that sclerostin is expressed by myeloma cells that are human myeloma cell lines and plasma cells (CD138(+) cells) obtained from the bone marrow (BM) of a large number of MM patients with bone disease. Moreover, we show that there are no differences in sclerostin serum levels between MM patients and controls. Thus, our data indicate that MM cells, as a sclerostin source in the BM, could create a microenvironment with high sclerostin concentration that could contribute toward inhibiting osteoblast differentiation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1237 |
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| Enthalten in: |
Annals of the New York Academy of Sciences - 1237(2011) vom: 14. Nov., Seite 19-23 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brunetti, Giacomina [VerfasserIn] |
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| Links: |
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| Themen: |
Adaptor Proteins, Signal Transducing |
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| Anmerkungen: |
Date Completed 05.01.2012 Date Revised 09.12.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.1111/j.1749-6632.2011.06196.x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM21302764X |
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| 245 | 1 | 0 | |a Sclerostin is overexpressed by plasma cells from multiple myeloma patients |
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| 520 | |a © 2011 New York Academy of Sciences. | ||
| 520 | |a Sclerostin, an osteocyte-expressed negative regulator of bone formation, is one of the inhibitors of Wnt signaling that is a critical pathway in the correct process of osteoblast differentiation. It has been demonstrated that Wnt signaling through the secretion of Wnt inhibitors, such as DKK1, sFRP-2, and sFRP-3, plays a key role in the decreased osteoblast activity associated with multiple myeloma (MM) bone disease. We provide evidence that sclerostin is expressed by myeloma cells that are human myeloma cell lines and plasma cells (CD138(+) cells) obtained from the bone marrow (BM) of a large number of MM patients with bone disease. Moreover, we show that there are no differences in sclerostin serum levels between MM patients and controls. Thus, our data indicate that MM cells, as a sclerostin source in the BM, could create a microenvironment with high sclerostin concentration that could contribute toward inhibiting osteoblast differentiation | ||
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| 700 | 1 | |a Oranger, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Mori, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Specchia, Giorgina |e verfasserin |4 aut | |
| 700 | 1 | |a Rinaldi, Erminia |e verfasserin |4 aut | |
| 700 | 1 | |a Curci, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Zallone, Alberta |e verfasserin |4 aut | |
| 700 | 1 | |a Rizzi, Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Grano, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Colucci, Silvia |e verfasserin |4 aut | |
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