In vitro combination effects of doripenem with aminoglycoside or ciprofloxacin against Pseudomonas aeruginosa
This study evaluated the in vitro activity of combinations of doripenem (DRPM) with aminoglycosides (tobramycin or amikacin) or fluoroquinolone (ciprofloxacin) against 92 isolates of Pseudomonas aeruginosa from 16 clinical facilities in 2004 in Japan. We also tested combination effect of other carbapenems (imipenem (IPM), meropenem, biapenem) with aminoglycosides or fluoroquinolone by checkerboard dilution methods. DRPM showed synergistic or additive effects with the aminoglycosides or the fluoroquinolone against 90% of the isolates. The combination of DRPM and aminoglycosides showed the strongest synergistic effects against IPM-intermediate resistant and IPM resistant strains among the tested combinations. These results suggested that combination of DRPM with aminoglycosides would be useful for the treatment of infections caused by P aeruginosa including IPM-resistant strains.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
|---|---|
| Enthalten in: |
The Japanese journal of antibiotics - 64(2011), 4 vom: 29. Aug., Seite 203-16 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Anan, Naomi [VerfasserIn] |
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| Anmerkungen: |
Date Completed 17.01.2012 Date Revised 01.12.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM212876473 |
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| 245 | 1 | 0 | |a In vitro combination effects of doripenem with aminoglycoside or ciprofloxacin against Pseudomonas aeruginosa |
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| 500 | |a Date Completed 17.01.2012 | ||
| 500 | |a Date Revised 01.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This study evaluated the in vitro activity of combinations of doripenem (DRPM) with aminoglycosides (tobramycin or amikacin) or fluoroquinolone (ciprofloxacin) against 92 isolates of Pseudomonas aeruginosa from 16 clinical facilities in 2004 in Japan. We also tested combination effect of other carbapenems (imipenem (IPM), meropenem, biapenem) with aminoglycosides or fluoroquinolone by checkerboard dilution methods. DRPM showed synergistic or additive effects with the aminoglycosides or the fluoroquinolone against 90% of the isolates. The combination of DRPM and aminoglycosides showed the strongest synergistic effects against IPM-intermediate resistant and IPM resistant strains among the tested combinations. These results suggested that combination of DRPM with aminoglycosides would be useful for the treatment of infections caused by P aeruginosa including IPM-resistant strains | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Aminoglycosides |2 NLM | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Anti-Infective Agents |2 NLM | |
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| 650 | 7 | |a Ciprofloxacin |2 NLM | |
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| 650 | 7 | |a Amikacin |2 NLM | |
| 650 | 7 | |a 84319SGC3C |2 NLM | |
| 650 | 7 | |a Doripenem |2 NLM | |
| 650 | 7 | |a BHV525JOBH |2 NLM | |
| 650 | 7 | |a Tobramycin |2 NLM | |
| 650 | 7 | |a VZ8RRZ51VK |2 NLM | |
| 700 | 1 | |a Toba, Shinsuke |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Akinobu |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Rio |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuji, Masakatsu |e verfasserin |4 aut | |
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