Brain function of heroin addicts after withdrawal
OBJECTIVE: To explore what brain regions are modulated by heroin addiction and withdrawal.
METHODS: We used functional magnetic resonance imaging to investigate the brain function in 15 heroin-dependent patients 3 days (acute) and 1 month (protracted) after heroin abstinence. Sixteen normal controls were included.
RESULTS: The blood oxygen level-dependent signal in the orbitofrontal cortex of the brain of heroin-dependent patients was significantly elevated 3 days after the withdrawal. Hyperfunction of the orbitofrontal cortex declined 1 month after the withdrawal.
CONCLUSION: Heroin-dependent subjects at both 3 days and 1 month abstinence have persistent abnormalities in the brain function. Although some tangible beneficial effects are noted following 1 month of detoxification, possible permanent damage to the brain caused by heroin use is suggested.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 36(2011), 8 vom: 12. Aug., Seite 733-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Xuyi [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 15.10.2012 Date Revised 22.09.2011 published: Print Citation Status MEDLINE |
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| doi: |
10.3969/j.issn.1672-7347.2011.08.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM211660787 |
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| 245 | 1 | 0 | |a Brain function of heroin addicts after withdrawal |
| 264 | 1 | |c 2011 | |
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| 500 | |a Date Completed 15.10.2012 | ||
| 500 | |a Date Revised 22.09.2011 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To explore what brain regions are modulated by heroin addiction and withdrawal | ||
| 520 | |a METHODS: We used functional magnetic resonance imaging to investigate the brain function in 15 heroin-dependent patients 3 days (acute) and 1 month (protracted) after heroin abstinence. Sixteen normal controls were included | ||
| 520 | |a RESULTS: The blood oxygen level-dependent signal in the orbitofrontal cortex of the brain of heroin-dependent patients was significantly elevated 3 days after the withdrawal. Hyperfunction of the orbitofrontal cortex declined 1 month after the withdrawal | ||
| 520 | |a CONCLUSION: Heroin-dependent subjects at both 3 days and 1 month abstinence have persistent abnormalities in the brain function. Although some tangible beneficial effects are noted following 1 month of detoxification, possible permanent damage to the brain caused by heroin use is suggested | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Zhou, Xuhui |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Yanhui |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Jinsong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Tieqiao |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Wei |e verfasserin |4 aut | |
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