In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis
Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
|---|---|
| Enthalten in: |
Revista do Instituto de Medicina Tropical de Sao Paulo - 53(2011), 4 vom: 07. Juli, Seite 235-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Blanco, Odalys [VerfasserIn] |
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| Themen: |
Antiprotozoal Agents |
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| Anmerkungen: |
Date Completed 03.02.2012 Date Revised 08.06.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM211451142 |
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| 245 | 1 | 0 | |a In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen® | ||
| 650 | 4 | |a Journal Article | |
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