Sensitization to ascaris lumbricoides and asthma severity in children

UNLABELLED: There is little information concerning asthma severity and sensitization to Ascaris lumbricoides in pediatric patients.

MATERIAL AND METHODS: The relationship between sensitization to Ascaris lumbricoides and asthma severity in 219 patients with a high prevalence of parasitic exposure (IgE antibodies) was studied by using linear, multivariate and logistic regression.

RESULTS: Sensitization to Ascaris lumbricoides was associated with positive skin tests for aeroallergens, increased total serum IgE, increased eosinophils, reductions in FEV1 and FEV1/FVC ratio, increased airway Methacholine, bronchodilator responsiveness, and hospitalizations for asthma in the past year.

CONCLUSIONS: Sensitization to Ascaris lumbricoides is associated with increased severity of asthma among Romanian children. This association is mediated by a high degree of atopy among the asthma children sensitized to Ascaris lumbricoides and belonging to a population with a low prevalence of helminthiasis.

Medienart:

Artikel

Erscheinungsjahr:

2011

Erschienen:

2011

Enthalten in:

Zur Gesamtaufnahme - volume:115

Enthalten in:

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi - 115(2011), 2 vom: 01. Apr., Seite 387-91

Sprache:

Rumänisch

Weiterer Titel:

Influenţa ascaridiozei asupra severităţii astmului bronşic la copil

Beteiligte Personen:

Rîpă, Carmen [VerfasserIn]
Bahnea, Roxana-Gabriela [VerfasserIn]
Cojocaru, Ingrid [VerfasserIn]
Luca, Mihaela Cătălina [VerfasserIn]
Leon, Maria [VerfasserIn]
Luca, Mariana [VerfasserIn]

Themen:

37341-29-0
Bronchodilator Agents
English Abstract
Immunoglobulin E
Immunologic Factors
Journal Article

Anmerkungen:

Date Completed 14.11.2011

Date Revised 29.08.2011

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM211029416