Hepatitis B; sometimes co-infection with hepatitis D
BACKGROUND: The Hepatitis delta virus (HDV) is a defect RNA virus that requires the presence of the hepatitis B virus (HBV) for cellular infection. Worldwide, 350 million people are infected with HBV; 5% of these are superinfected with HDV. A chronic superinfection with HDV has a higher morbidity and mortality rate. It is clinically difficult to differentiate between an HBV and an HDV infection. Diagnosis is made via detection of HDV antibodies and HDV-RNA using PCR techniques. The only treatment option is peginterferon-alpha 180 μg subcutaneously once a week for 48 weeks.
CASE DESCRIPTION: A 37-year-old man with a Syrian background and a chronic HBV infection presented with high levels of ALT indicating severe hepatitis. The level of detected HBV-DNA-particles was low, however, indicating that the HBV infection alone could not be responsible for the inflammation. Further investigations revealed a superinfection with HDV. The patient was successfully treated with peginterferon-alpha.
CONCLUSION: Severe hepatitis (high ALT level) in combination with a low HBV-DNA-particle level can indicate a HDV superinfection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:155 |
|---|---|
| Enthalten in: |
Nederlands tijdschrift voor geneeskunde - 155(2011), 33 vom: 22., Seite A3513 |
| Sprache: |
Niederländisch |
|---|
| Weiterer Titel: |
Hepatitis B; soms ook samen met hepatitis D |
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| Beteiligte Personen: |
Derikx, Monique H M [VerfasserIn] |
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| Themen: |
Antiviral Agents |
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| Anmerkungen: |
Date Completed 09.11.2011 Date Revised 22.08.2011 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
|
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| PPN (Katalog-ID): |
NLM210875801 |
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| 100 | 1 | |a Derikx, Monique H M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hepatitis B; sometimes co-infection with hepatitis D |
| 246 | 3 | 3 | |a Hepatitis B; soms ook samen met hepatitis D |
| 264 | 1 | |c 2011 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 09.11.2011 | ||
| 500 | |a Date Revised 22.08.2011 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The Hepatitis delta virus (HDV) is a defect RNA virus that requires the presence of the hepatitis B virus (HBV) for cellular infection. Worldwide, 350 million people are infected with HBV; 5% of these are superinfected with HDV. A chronic superinfection with HDV has a higher morbidity and mortality rate. It is clinically difficult to differentiate between an HBV and an HDV infection. Diagnosis is made via detection of HDV antibodies and HDV-RNA using PCR techniques. The only treatment option is peginterferon-alpha 180 μg subcutaneously once a week for 48 weeks | ||
| 520 | |a CASE DESCRIPTION: A 37-year-old man with a Syrian background and a chronic HBV infection presented with high levels of ALT indicating severe hepatitis. The level of detected HBV-DNA-particles was low, however, indicating that the HBV infection alone could not be responsible for the inflammation. Further investigations revealed a superinfection with HDV. The patient was successfully treated with peginterferon-alpha | ||
| 520 | |a CONCLUSION: Severe hepatitis (high ALT level) in combination with a low HBV-DNA-particle level can indicate a HDV superinfection | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a DNA, Viral |2 NLM | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a Spanier, B W Marcel |e verfasserin |4 aut | |
| 700 | 1 | |a Vrolijk, Jan Maarten |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nederlands tijdschrift voor geneeskunde |d 1946 |g 155(2011), 33 vom: 22., Seite A3513 |w (DE-627)NLM000034231 |x 1876-8784 |7 nnns |
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