Is cell death induced by nematocysts extract of medusa Pelagia noctiluca related to oxidative stress?
Copyright © 2011 Wiley Periodicals, Inc., a Wiley company..
Pelagia noctiluca, a jellyfish widely distributed in the Mediterranean waters, especially in coastal areas of Tunisia, has garnered attention because of its stinging capacity and the resulting public health hazard. Crude extracts of P. noctiluca nematocysts have been tested for their cytotoxicity on Vero cells. Our results clearly showed that nematocysts induced cell mortality in a dose- and time-dependent manner. A cytoprotective effect against cell mortality was obtained when Vero cells were treated with Vitamin E. This process was further confirmed by the generation of reactive oxygen species (ROS) and the induction of Hsp 70 and 27 protein expressions. Thus, our findings suggested that oxidative stress is involved in the toxicity of pelagia nematocysts and may therefore constitute the major mechanism of this medusa nematocysts toxicity.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2013 |
|---|---|
| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Environmental toxicology - 28(2013), 9 vom: 04. Sept., Seite 498-506 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ayed, Yosra [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 25.11.2013 Date Revised 10.12.2019 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/tox.20740 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM210442034 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM210442034 | ||
| 003 | DE-627 | ||
| 005 | 20231224011649.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/tox.20740 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0701.xml |
| 035 | |a (DE-627)NLM210442034 | ||
| 035 | |a (NLM)21809431 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ayed, Yosra |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Is cell death induced by nematocysts extract of medusa Pelagia noctiluca related to oxidative stress? |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.11.2013 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2011 Wiley Periodicals, Inc., a Wiley company. | ||
| 520 | |a Pelagia noctiluca, a jellyfish widely distributed in the Mediterranean waters, especially in coastal areas of Tunisia, has garnered attention because of its stinging capacity and the resulting public health hazard. Crude extracts of P. noctiluca nematocysts have been tested for their cytotoxicity on Vero cells. Our results clearly showed that nematocysts induced cell mortality in a dose- and time-dependent manner. A cytoprotective effect against cell mortality was obtained when Vero cells were treated with Vitamin E. This process was further confirmed by the generation of reactive oxygen species (ROS) and the induction of Hsp 70 and 27 protein expressions. Thus, our findings suggested that oxidative stress is involved in the toxicity of pelagia nematocysts and may therefore constitute the major mechanism of this medusa nematocysts toxicity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Hsp 27 | |
| 650 | 4 | |a Hsp 70 | |
| 650 | 4 | |a Pelagia noctiluca | |
| 650 | 4 | |a ROS | |
| 650 | 4 | |a Vitamin E | |
| 650 | 4 | |a nematocysts venom | |
| 650 | 7 | |a Cnidarian Venoms |2 NLM | |
| 650 | 7 | |a Cytotoxins |2 NLM | |
| 650 | 7 | |a HSP27 Heat-Shock Proteins |2 NLM | |
| 650 | 7 | |a HSP70 Heat-Shock Proteins |2 NLM | |
| 650 | 7 | |a Reactive Oxygen Species |2 NLM | |
| 650 | 7 | |a Tissue Extracts |2 NLM | |
| 650 | 7 | |a Vitamin E |2 NLM | |
| 650 | 7 | |a 1406-18-4 |2 NLM | |
| 700 | 1 | |a Chayma, Bouaziz |e verfasserin |4 aut | |
| 700 | 1 | |a Hayla, Abassi |e verfasserin |4 aut | |
| 700 | 1 | |a Abid, Salwa |e verfasserin |4 aut | |
| 700 | 1 | |a Bacha, Hassen |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Environmental toxicology |d 2001 |g 28(2013), 9 vom: 04. Sept., Seite 498-506 |w (DE-627)NLM112466567 |x 1522-7278 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2013 |g number:9 |g day:04 |g month:09 |g pages:498-506 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/tox.20740 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2013 |e 9 |b 04 |c 09 |h 498-506 | ||