Intrathecal sufentanil versus fentanyl for lower limb surgeries - a randomized controlled trial
BACKGROUND: To compare the efficacy and safety of intrathecal sufentanil or fentanyl as adjuvants to hyperbaric bupivacaine in patients undergoing major orthopaedic lower limb surgeries in terms of onset and duration of sensory block, motor block and post-operative pain relief. PATIENTS #ENTITYSTARTX00026;.
METHODS: Ninety patients were recruited in this Prospective, randomized double blind study to receive either intrathecal sufentanil 5 μg (Group S), fentanyl 25 μg (Group F) or normal saline 0.5 ml (Group C) as adjuvants to 15 mg of 0.5% hyperbaric bupivacaine. The onset and duration of sensory and motor block were assessed intraoperatively. The pain scores were assessed postoperatively. Duration of complete and effective analgesia was recorded. The incidence of side effects such as nausea, vomiting, pruritus, shivering and PDPH was recorded.
RESULTS: The Demographic data, hemodynamic and respiratory parameters were comparable in the three groups. There was a significantly earlier onset and prolonged duration of sensory block in the sufentanil and fentanyl groups. The duration of complete and effective analgesia were also significantly prolonged in the fentanyl and sufentanil groups. Pruritus was noticed in the study groups (Groups S&F).
CONCLUSIONS: Intrathecal sufentanil (5 μg) and fentanyl (25 μg), as adjuvants lead to an earlier onset and prolonged duration of sensory block. The duration of effective analgesia with intrathecal sufentanil and fentanyl as adjuvants to hyperbaric bupivacaine is longer than that of bupivacaine alone.
Errataetall: |
RetractionIn: J Anaesthesiol Clin Pharmacol. 2016 Jan-Mar;32(1):133. - PMID 27006570 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2011 |
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Erschienen: |
2011 |
Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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Enthalten in: |
Journal of anaesthesiology, clinical pharmacology - 27(2011), 1 vom: 05. Jan., Seite 67-73 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Motiani, Poonam [VerfasserIn] |
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Themen: |
Intrathecal adjuvant, Fentanyl |
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Anmerkungen: |
Date Completed 10.11.2011 Date Revised 17.03.2022 published: Print RetractionIn: J Anaesthesiol Clin Pharmacol. 2016 Jan-Mar;32(1):133. - PMID 27006570 Citation Status PubMed-not-MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM210396350 |
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245 | 1 | 0 | |a Intrathecal sufentanil versus fentanyl for lower limb surgeries - a randomized controlled trial |
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500 | |a RetractionIn: J Anaesthesiol Clin Pharmacol. 2016 Jan-Mar;32(1):133. - PMID 27006570 | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a BACKGROUND: To compare the efficacy and safety of intrathecal sufentanil or fentanyl as adjuvants to hyperbaric bupivacaine in patients undergoing major orthopaedic lower limb surgeries in terms of onset and duration of sensory block, motor block and post-operative pain relief. PATIENTS #ENTITYSTARTX00026; | ||
520 | |a METHODS: Ninety patients were recruited in this Prospective, randomized double blind study to receive either intrathecal sufentanil 5 μg (Group S), fentanyl 25 μg (Group F) or normal saline 0.5 ml (Group C) as adjuvants to 15 mg of 0.5% hyperbaric bupivacaine. The onset and duration of sensory and motor block were assessed intraoperatively. The pain scores were assessed postoperatively. Duration of complete and effective analgesia was recorded. The incidence of side effects such as nausea, vomiting, pruritus, shivering and PDPH was recorded | ||
520 | |a RESULTS: The Demographic data, hemodynamic and respiratory parameters were comparable in the three groups. There was a significantly earlier onset and prolonged duration of sensory block in the sufentanil and fentanyl groups. The duration of complete and effective analgesia were also significantly prolonged in the fentanyl and sufentanil groups. Pruritus was noticed in the study groups (Groups S&F) | ||
520 | |a CONCLUSIONS: Intrathecal sufentanil (5 μg) and fentanyl (25 μg), as adjuvants lead to an earlier onset and prolonged duration of sensory block. The duration of effective analgesia with intrathecal sufentanil and fentanyl as adjuvants to hyperbaric bupivacaine is longer than that of bupivacaine alone | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Retracted Publication | |
650 | 4 | |a Intrathecal adjuvant, Fentanyl | |
650 | 4 | |a Sufentanil, Lower limb surgeries | |
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700 | 1 | |a Sethi, A K |e verfasserin |4 aut | |
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