Tailoring adjuvant radiotherapy for stage IB-IIA node negative cervical carcinoma after radical hysterectomy and pelvic lymph node dissection using the GOG score
Copyright © 2011 Elsevier Inc. All rights reserved..
OBJECTIVE: The use of adjuvant radiotherapy for early stage node negative patients varies for different institutions. The recognized factors such as deep stromal invasion, lymph vascular space invasion, and size of tumor are the most common factors cited for adjuvant radiotherapy. Studies done have shown that this increases local control but may increase chronic toxicity rates. We report on our use of the GOG score to tailor our treatment decisions.
METHODS: A review of all patients staged IB-IIA who underwent Type 3 Radical Hysterectomy and pelvic lymph node dissection (RH) from 1997 to 2007. The GOG score proposed by Delgado et al. was applied, and patients were stratified into 3 groups; <40: no adjuvant treatment, 40-120: Small Field RT (SmRT), and >120: Standard Field RT (StRT) RESULTS: A total of 126 patients matched these criteria. Sixty one patients underwent either SmRT or StRT. There were only 2 known relapses and one death due to inter current illness. The median follow up was 57 months and the 5 year Disease Free Survival was 98.2%. There were no documented Grade 3 or 4 chronic toxicities. There were significantly less (p=0.025) patients with lower limb lymphedema in the SmRT group compared to StRT.
CONCLUSION: Our study confirms the utility of the GOG score to tailor radiotherapy for this cohort of patients. This has been proven to be high in efficacy and low in morbidity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:123 |
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| Enthalten in: |
Gynecologic oncology - 123(2011), 2 vom: 15. Nov., Seite 225-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yeo, Richard M C [VerfasserIn] |
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| Anmerkungen: |
Date Completed 07.12.2011 Date Revised 19.10.2011 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ygyno.2011.06.040 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM210174986 |
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| 100 | 1 | |a Yeo, Richard M C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tailoring adjuvant radiotherapy for stage IB-IIA node negative cervical carcinoma after radical hysterectomy and pelvic lymph node dissection using the GOG score |
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| 500 | |a Date Completed 07.12.2011 | ||
| 500 | |a Date Revised 19.10.2011 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2011 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: The use of adjuvant radiotherapy for early stage node negative patients varies for different institutions. The recognized factors such as deep stromal invasion, lymph vascular space invasion, and size of tumor are the most common factors cited for adjuvant radiotherapy. Studies done have shown that this increases local control but may increase chronic toxicity rates. We report on our use of the GOG score to tailor our treatment decisions | ||
| 520 | |a METHODS: A review of all patients staged IB-IIA who underwent Type 3 Radical Hysterectomy and pelvic lymph node dissection (RH) from 1997 to 2007. The GOG score proposed by Delgado et al. was applied, and patients were stratified into 3 groups; <40: no adjuvant treatment, 40-120: Small Field RT (SmRT), and >120: Standard Field RT (StRT) RESULTS: A total of 126 patients matched these criteria. Sixty one patients underwent either SmRT or StRT. There were only 2 known relapses and one death due to inter current illness. The median follow up was 57 months and the 5 year Disease Free Survival was 98.2%. There were no documented Grade 3 or 4 chronic toxicities. There were significantly less (p=0.025) patients with lower limb lymphedema in the SmRT group compared to StRT | ||
| 520 | |a CONCLUSION: Our study confirms the utility of the GOG score to tailor radiotherapy for this cohort of patients. This has been proven to be high in efficacy and low in morbidity | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Chia, Yin N |e verfasserin |4 aut | |
| 700 | 1 | |a Namuduri, Rama P D |e verfasserin |4 aut | |
| 700 | 1 | |a Yap, Swee P |e verfasserin |4 aut | |
| 700 | 1 | |a Soong, Yoke L |e verfasserin |4 aut | |
| 700 | 1 | |a Yam, Philip K L |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Timothy Y K |e verfasserin |4 aut | |
| 700 | 1 | |a Khoo-Tan, Hoon S |e verfasserin |4 aut | |
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