Exogenous Cushing's syndrome as a serious side-effect of therapy with ritonavir an inhaled fluticasone
Inhalation of fluticasone is usually devoid of systemic side-effects. The authors describe a case of a young HIV positive woman treated concomitantly with fluticasone and inhibitors of HIV protease ritonavir and lopinavir in which developed a serious endocrine side-effect - an iatrogenic Cushing's syndrome. Plasma concentration of cortisol < 5.5 nmol/l was very low (norm 250-650 nmol/l) and plasmatic ACTH was even not detectable. The administration of fluticasone and both inhibitors of HIV protease was stopped and substitution therapy with decreasing dose of hydrocortisone was initiated. Twenty weeks later resolved both clinical and laboratory symptoms of Cushing's syndrome, and the substitution therapy with hydrocortisone was terminated. Two years later became the patient pregnant and gave birth to a healthy child.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2011 |
|---|---|
| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
|---|---|
| Enthalten in: |
Klinicka mikrobiologie a infekcni lekarstvi - 17(2011), 3 vom: 01. Juni, Seite 103-5 |
| Sprache: |
Tschechisch |
|---|
| Weiterer Titel: |
Exogenni Gushinguv syndrom jako zavazny nezadouci ucinek lecby ritonavirem a inhalacnim flutikazonem |
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| Beteiligte Personen: |
Machala, Ladislav [VerfasserIn] |
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| Themen: |
Androstadienes |
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| Anmerkungen: |
Date Completed 30.08.2011 Date Revised 19.11.2015 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM210153709 |
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| 245 | 1 | 0 | |a Exogenous Cushing's syndrome as a serious side-effect of therapy with ritonavir an inhaled fluticasone |
| 246 | 3 | 3 | |a Exogenni Gushinguv syndrom jako zavazny nezadouci ucinek lecby ritonavirem a inhalacnim flutikazonem |
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| 500 | |a Date Completed 30.08.2011 | ||
| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Inhalation of fluticasone is usually devoid of systemic side-effects. The authors describe a case of a young HIV positive woman treated concomitantly with fluticasone and inhibitors of HIV protease ritonavir and lopinavir in which developed a serious endocrine side-effect - an iatrogenic Cushing's syndrome. Plasma concentration of cortisol < 5.5 nmol/l was very low (norm 250-650 nmol/l) and plasmatic ACTH was even not detectable. The administration of fluticasone and both inhibitors of HIV protease was stopped and substitution therapy with decreasing dose of hydrocortisone was initiated. Twenty weeks later resolved both clinical and laboratory symptoms of Cushing's syndrome, and the substitution therapy with hydrocortisone was terminated. Two years later became the patient pregnant and gave birth to a healthy child | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Anti-Allergic Agents |2 NLM | |
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| 700 | 1 | |a Kréze, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Jilich, David |e verfasserin |4 aut | |
| 700 | 1 | |a Rozsypal, Hanuš |e verfasserin |4 aut | |
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