Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
Copyright © 2011 Elsevier Inc. All rights reserved..
Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1). However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1, CDO, and BOC, as putative coreceptors for HH ligands. A central question is to what degree these coreceptors function similarly and what their collective requirement in HH signal transduction is. Here we provide evidence that GAS1, CDO, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube. Specifically, we demonstrate two important roles for these molecules: an early role in cell fate specification of multiple neural progenitors and a later role in motor neuron progenitor maintenance. Most strikingly, genetic loss-of-function experiments indicate an obligatory requirement for GAS1, CDO, and BOC in HH pathway activity in multiple tissues.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2011 |
|---|---|
| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
|---|---|
| Enthalten in: |
Developmental cell - 20(2011), 6 vom: 14. Juni, Seite 775-87 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Allen, Benjamin L [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 16.08.2011 Date Revised 20.10.2021 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.devcel.2011.04.018 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM209083530 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM209083530 | ||
| 003 | DE-627 | ||
| 005 | 20231224005133.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.devcel.2011.04.018 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0697.xml |
| 035 | |a (DE-627)NLM209083530 | ||
| 035 | |a (NLM)21664576 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Allen, Benjamin L |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function |
| 264 | 1 | |c 2011 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.08.2011 | ||
| 500 | |a Date Revised 20.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2011 Elsevier Inc. All rights reserved. | ||
| 520 | |a Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1). However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1, CDO, and BOC, as putative coreceptors for HH ligands. A central question is to what degree these coreceptors function similarly and what their collective requirement in HH signal transduction is. Here we provide evidence that GAS1, CDO, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube. Specifically, we demonstrate two important roles for these molecules: an early role in cell fate specification of multiple neural progenitors and a later role in motor neuron progenitor maintenance. Most strikingly, genetic loss-of-function experiments indicate an obligatory requirement for GAS1, CDO, and BOC in HH pathway activity in multiple tissues | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Boc protein, mouse |2 NLM | |
| 650 | 7 | |a Cdon protein, mouse |2 NLM | |
| 650 | 7 | |a Cell Adhesion Molecules |2 NLM | |
| 650 | 7 | |a Cell Cycle Proteins |2 NLM | |
| 650 | 7 | |a GPI-Linked Proteins |2 NLM | |
| 650 | 7 | |a Gas1 protein, mouse |2 NLM | |
| 650 | 7 | |a Gli2 protein, mouse |2 NLM | |
| 650 | 7 | |a Hedgehog Proteins |2 NLM | |
| 650 | 7 | |a Immunoglobulin G |2 NLM | |
| 650 | 7 | |a Kruppel-Like Transcription Factors |2 NLM | |
| 650 | 7 | |a Receptors, Cell Surface |2 NLM | |
| 650 | 7 | |a Shh protein, mouse |2 NLM | |
| 650 | 7 | |a Zinc Finger Protein Gli2 |2 NLM | |
| 700 | 1 | |a Song, Jane Y |e verfasserin |4 aut | |
| 700 | 1 | |a Izzi, Luisa |e verfasserin |4 aut | |
| 700 | 1 | |a Althaus, Irene W |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Jong-Sun |e verfasserin |4 aut | |
| 700 | 1 | |a Charron, Frédéric |e verfasserin |4 aut | |
| 700 | 1 | |a Krauss, Robert S |e verfasserin |4 aut | |
| 700 | 1 | |a McMahon, Andrew P |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Developmental cell |d 2001 |g 20(2011), 6 vom: 14. Juni, Seite 775-87 |w (DE-627)NLM115954538 |x 1878-1551 |7 nnns |
| 773 | 1 | 8 | |g volume:20 |g year:2011 |g number:6 |g day:14 |g month:06 |g pages:775-87 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.devcel.2011.04.018 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 20 |j 2011 |e 6 |b 14 |c 06 |h 775-87 | ||