The potent anti-inflammatory agent escin does not increase corticosterone secretion and immune cell apoptosis in mice
Copyright © 2011 Elsevier B.V. All rights reserved..
Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 days before observing the relevant parameters. The results showed that escin exhibits a potent anti-inflammatory effect, but does not increase corticosterone secretion in mice, and does not increase immune cell apoptosis in the spleen and thymus of mice. These findings suggest that the anti-inflammatory effect of escin is not dependent on the release of corticosterone.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
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| Enthalten in: |
Fitoterapia - 82(2011), 6 vom: 11. Sept., Seite 861-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Leiming [VerfasserIn] |
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| Links: |
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| Themen: |
6805-41-0 |
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| Anmerkungen: |
Date Completed 08.04.2013 Date Revised 21.11.2013 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fitote.2011.04.004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM20846297X |
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| 245 | 1 | 4 | |a The potent anti-inflammatory agent escin does not increase corticosterone secretion and immune cell apoptosis in mice |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2011 Elsevier B.V. All rights reserved. | ||
| 520 | |a Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 days before observing the relevant parameters. The results showed that escin exhibits a potent anti-inflammatory effect, but does not increase corticosterone secretion in mice, and does not increase immune cell apoptosis in the spleen and thymus of mice. These findings suggest that the anti-inflammatory effect of escin is not dependent on the release of corticosterone | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Fan, Huaying |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Tian |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Na |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Pengfei |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Fenghua |e verfasserin |4 aut | |
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