Hepatocellular carcinoma arising in a pigmented telangiectatic adenoma with nuclear β-catenin and glutamine synthetase positivity : case report and review of the literature
Telangiectatic hepatocellular adenoma is a rare, recently recognized subtype of hepatocellular adenoma that is often underrecognized by pathologists. We report a case of hepatocellular carcinoma arising within a pigmented telangiectatic hepatocellular adenoma in a noncirrhotic man with diffuse glutamine synthetase and nuclear β-catenin positivity. This case highlights malignant transformation of telangiectatic adenomas, and describes a previously unreported association between pigment deposition and telangiectatic adenoma. Radiology, gross pathology, and histopathology are shown. Review of the literature with attention to β-catenin and glutamine synthetase staining, malignant transformation, patient characteristics, the presence of Dubin-Johnson-like pigment, and genetic characteristics of telangiectatic adenomas are discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
The American journal of surgical pathology - 35(2011), 6 vom: 01. Juni, Seite 927-32 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hechtman, Jaclyn F [VerfasserIn] |
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| Links: |
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| Themen: |
Beta Catenin |
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| Anmerkungen: |
Date Completed 12.07.2011 Date Revised 19.11.2015 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/PAS.0b013e318218ca3f |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM208230513 |
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| 100 | 1 | |a Hechtman, Jaclyn F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hepatocellular carcinoma arising in a pigmented telangiectatic adenoma with nuclear β-catenin and glutamine synthetase positivity |b case report and review of the literature |
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| 500 | |a Date Completed 12.07.2011 | ||
| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Telangiectatic hepatocellular adenoma is a rare, recently recognized subtype of hepatocellular adenoma that is often underrecognized by pathologists. We report a case of hepatocellular carcinoma arising within a pigmented telangiectatic hepatocellular adenoma in a noncirrhotic man with diffuse glutamine synthetase and nuclear β-catenin positivity. This case highlights malignant transformation of telangiectatic adenomas, and describes a previously unreported association between pigment deposition and telangiectatic adenoma. Radiology, gross pathology, and histopathology are shown. Review of the literature with attention to β-catenin and glutamine synthetase staining, malignant transformation, patient characteristics, the presence of Dubin-Johnson-like pigment, and genetic characteristics of telangiectatic adenomas are discussed | ||
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| 700 | 1 | |a Facciuto, Marcelo |e verfasserin |4 aut | |
| 700 | 1 | |a Schiano, Thomas D |e verfasserin |4 aut | |
| 700 | 1 | |a Blouin, Amanda G |e verfasserin |4 aut | |
| 700 | 1 | |a Thung, Swan N |e verfasserin |4 aut | |
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