The utility of QuantiFERON TB Gold for diagnosing tuberculous meningitis in children
MATERIAL AND METHODS: We performed QuantiFERON-TB Gold in Tube (QFT-G) in blood and CSF at 40 children diagnosed with TB meningitis and at 39 children with non TB meningitis, admitted between October 2006 and December 2009.
RESULTS: The CSF analyses were suggestive for TB at 27 patients and only 14 had positive culture. The sensitivity of QFT-G in CSF was 72.72% and 69.44% in blood; specificity 96.96% in CSF and 89.18% in blood; the positive predictive value was 96% in CSF and 86.2% in blood; negative predictive value was 78.04% in CSF and 75% in blood. The sensitivity of TST was 61.76% and specificity 82.05%. The sensitivity of the culture from CSF was only 35%. The sensitivity and specificity of QFT-G was higher than TST and culture and better in CSF than in blood.
CONCLUSIONS: The determination of alpha-interferon in serum and CSF is useful diagnostic marker of tuberculosis who could improve the management of TB meningitis.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2010 |
|---|---|
| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:114 |
|---|---|
| Enthalten in: |
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi - 114(2010), 4 vom: 30. Okt., Seite 1048-52 |
| Sprache: |
Rumänisch |
|---|
| Weiterer Titel: |
Utilitatea testului quantiFERON TB gold in diagnosticul meningitei tuberculoase la copil |
|---|
| Beteiligte Personen: |
Căliman-Sturdza, Olga Adriana [VerfasserIn] |
|---|
| Themen: |
82115-62-6 |
|---|
| Anmerkungen: |
Date Completed 08.07.2011 Date Revised 19.11.2015 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM207544549 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM207544549 | ||
| 003 | DE-627 | ||
| 005 | 20231224002312.0 | ||
| 007 | tu | ||
| 008 | 231224s2010 xx ||||| 00| ||rum c | ||
| 028 | 5 | 2 | |a pubmed24n0692.xml |
| 035 | |a (DE-627)NLM207544549 | ||
| 035 | |a (NLM)21500458 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a rum | ||
| 100 | 1 | |a Căliman-Sturdza, Olga Adriana |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The utility of QuantiFERON TB Gold for diagnosing tuberculous meningitis in children |
| 246 | 3 | 3 | |a Utilitatea testului quantiFERON TB gold in diagnosticul meningitei tuberculoase la copil |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 08.07.2011 | ||
| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a MATERIAL AND METHODS: We performed QuantiFERON-TB Gold in Tube (QFT-G) in blood and CSF at 40 children diagnosed with TB meningitis and at 39 children with non TB meningitis, admitted between October 2006 and December 2009 | ||
| 520 | |a RESULTS: The CSF analyses were suggestive for TB at 27 patients and only 14 had positive culture. The sensitivity of QFT-G in CSF was 72.72% and 69.44% in blood; specificity 96.96% in CSF and 89.18% in blood; the positive predictive value was 96% in CSF and 86.2% in blood; negative predictive value was 78.04% in CSF and 75% in blood. The sensitivity of TST was 61.76% and specificity 82.05%. The sensitivity of the culture from CSF was only 35%. The sensitivity and specificity of QFT-G was higher than TST and culture and better in CSF than in blood | ||
| 520 | |a CONCLUSIONS: The determination of alpha-interferon in serum and CSF is useful diagnostic marker of tuberculosis who could improve the management of TB meningitis | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Immunologic Factors |2 NLM | |
| 650 | 7 | |a Reagent Kits, Diagnostic |2 NLM | |
| 650 | 7 | |a Interferon-gamma |2 NLM | |
| 650 | 7 | |a 82115-62-6 |2 NLM | |
| 700 | 1 | |a Mihalache, Doina |e verfasserin |4 aut | |
| 700 | 1 | |a Luca, Catalina Mihaela |e verfasserin |4 aut | |
| 700 | 1 | |a Petrovici, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Dorobăţ, Carmen Mihaela |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi |d 1961 |g 114(2010), 4 vom: 30. Okt., Seite 1048-52 |w (DE-627)NLM000103667 |x 0048-7848 |7 nnns |
| 773 | 1 | 8 | |g volume:114 |g year:2010 |g number:4 |g day:30 |g month:10 |g pages:1048-52 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 114 |j 2010 |e 4 |b 30 |c 10 |h 1048-52 | ||