Prevention of nosocomial transmission of norovirus by strategic infection control measures
BACKGROUND: Nosocomial outbreaks of norovirus infection pose a great challenge to the infection control team.
METHODS: Between November 1, 2009, and February 28, 2010, strategic infection control measures were implemented in a hospital network. In addition to timely staff education and promotion of directly observed hand hygiene, reverse-transcription polymerase chain reaction for norovirus was performed as an added test by the microbiology laboratory for all fecal specimens irrespective of the request for testing. Laboratory-confirmed cases were followed up by the infection control team for timely intervention. The incidence of hospital-acquired norovirus infection per 1,000 potentially infectious patient-days was compared with the corresponding period in the preceding 12 months, and the incidence in the other 6 hospital networks in Hong Kong was chosen as the concurrent control. Phylogenetic analysis of norovirus isolates was performed.
RESULTS: Of the 988 patients who were tested, 242 (25%) were positive for norovirus; 114 (47%) of those 242 patients had norovirus detected by our added test. Compared with the corresponding period in the preceding 12 months, the incidence of hospital-acquired norovirus infection decreased from 131 to 16 cases per 1,000 potentially infectious patient-days (P < .001), although the number of hospital-acquired infections was low in both the study period (n = 8) and the historical control periods (n = 11). The incidence of hospital-acquired norovirus infection in our hospital network (0.03 cases per 1,000 patient-days) was significantly lower than that of the concurrent control (0.06 cases per 1,000 patient-days) (P = .015). Forty-three (93%) of 46 norovirus isolates sequenced belonged to the genogroup II.4 variant.
CONCLUSIONS: Strategic infection control measures with an added test may be useful in controlling nosocomial transmission of norovirus.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Infection control and hospital epidemiology - 32(2011), 3 vom: 20. März, Seite 229-37 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cheng, Vincent C C [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.07.2011 Date Revised 27.01.2015 published: Print Citation Status MEDLINE |
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| doi: |
10.1086/658330 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM207168512 |
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| 100 | 1 | |a Cheng, Vincent C C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevention of nosocomial transmission of norovirus by strategic infection control measures |
| 264 | 1 | |c 2011 | |
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| 500 | |a Date Completed 28.07.2011 | ||
| 500 | |a Date Revised 27.01.2015 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Nosocomial outbreaks of norovirus infection pose a great challenge to the infection control team | ||
| 520 | |a METHODS: Between November 1, 2009, and February 28, 2010, strategic infection control measures were implemented in a hospital network. In addition to timely staff education and promotion of directly observed hand hygiene, reverse-transcription polymerase chain reaction for norovirus was performed as an added test by the microbiology laboratory for all fecal specimens irrespective of the request for testing. Laboratory-confirmed cases were followed up by the infection control team for timely intervention. The incidence of hospital-acquired norovirus infection per 1,000 potentially infectious patient-days was compared with the corresponding period in the preceding 12 months, and the incidence in the other 6 hospital networks in Hong Kong was chosen as the concurrent control. Phylogenetic analysis of norovirus isolates was performed | ||
| 520 | |a RESULTS: Of the 988 patients who were tested, 242 (25%) were positive for norovirus; 114 (47%) of those 242 patients had norovirus detected by our added test. Compared with the corresponding period in the preceding 12 months, the incidence of hospital-acquired norovirus infection decreased from 131 to 16 cases per 1,000 potentially infectious patient-days (P < .001), although the number of hospital-acquired infections was low in both the study period (n = 8) and the historical control periods (n = 11). The incidence of hospital-acquired norovirus infection in our hospital network (0.03 cases per 1,000 patient-days) was significantly lower than that of the concurrent control (0.06 cases per 1,000 patient-days) (P = .015). Forty-three (93%) of 46 norovirus isolates sequenced belonged to the genogroup II.4 variant | ||
| 520 | |a CONCLUSIONS: Strategic infection control measures with an added test may be useful in controlling nosocomial transmission of norovirus | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a DNA, Viral |2 NLM | |
| 700 | 1 | |a Wong, Lisa M W |e verfasserin |4 aut | |
| 700 | 1 | |a Tai, Josepha W M |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Jasper F W |e verfasserin |4 aut | |
| 700 | 1 | |a To, Kelvin K W |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Iris W S |e verfasserin |4 aut | |
| 700 | 1 | |a Hung, Ivan F N |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, K H |e verfasserin |4 aut | |
| 700 | 1 | |a Ho, P L |e verfasserin |4 aut | |
| 700 | 1 | |a Yuen, K Y |e verfasserin |4 aut | |
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