Effect of baicalin on pharmacokinetics of chlorogenic acid in rabbits
OBJECTIVE: The objective of this paper is to investigate the pharmacokinetics of Chlorogenic acid (CA)and CA-Baicalin compound after intravenous injection (iv) in rabbits.
METHOD: Ten rabbits were randomly divided into two groups. One group were administered CA (6 mg x kg(-1)) by iv, while the other were treated with CA (6 mg x kg(-1))-baicalin (90 mg x kg(-1)) compound by iv. administration. The concentration of CA in plasma was determined by HPLC. The key parameters of pharmacokinetics were calculated and analyzed by kinetic software.
RESULT: Both Concentration-time courses of CA alone and CA-Baicalin compound were consistent with a two-compartment model after administration. The key pharmacokinetic parameters of CA alone were significantly different from that of CA-Baicalin compound (P < 0.05). Compared with the group treated with CA alone, the group treated with CA-Baicalin compound had dramatic increased in AUC(0-infinity), MRT and T1/2alpha.
CONCLUSION: There are significant difference between the pharmacokinetics of CA and CA-Baicalin compound in rabbits. Baicalin has impact on the pharmacokinetics of CA in rabbits.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2010 |
|---|---|
| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
|---|---|
| Enthalten in: |
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica - 35(2010), 24 vom: 01. Dez., Seite 3291-3 |
| Sprache: |
Chinesisch |
|---|
| Beteiligte Personen: |
Li, Zhaoxi [VerfasserIn] |
|---|
| Themen: |
318ADP12RI |
|---|
| Anmerkungen: |
Date Completed 12.04.2011 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM20696059X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
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| 041 | |a chi | ||
| 100 | 1 | |a Li, Zhaoxi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of baicalin on pharmacokinetics of chlorogenic acid in rabbits |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 12.04.2011 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: The objective of this paper is to investigate the pharmacokinetics of Chlorogenic acid (CA)and CA-Baicalin compound after intravenous injection (iv) in rabbits | ||
| 520 | |a METHOD: Ten rabbits were randomly divided into two groups. One group were administered CA (6 mg x kg(-1)) by iv, while the other were treated with CA (6 mg x kg(-1))-baicalin (90 mg x kg(-1)) compound by iv. administration. The concentration of CA in plasma was determined by HPLC. The key parameters of pharmacokinetics were calculated and analyzed by kinetic software | ||
| 520 | |a RESULT: Both Concentration-time courses of CA alone and CA-Baicalin compound were consistent with a two-compartment model after administration. The key pharmacokinetic parameters of CA alone were significantly different from that of CA-Baicalin compound (P < 0.05). Compared with the group treated with CA alone, the group treated with CA-Baicalin compound had dramatic increased in AUC(0-infinity), MRT and T1/2alpha | ||
| 520 | |a CONCLUSION: There are significant difference between the pharmacokinetics of CA and CA-Baicalin compound in rabbits. Baicalin has impact on the pharmacokinetics of CA in rabbits | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Flavonoids |2 NLM | |
| 650 | 7 | |a Chlorogenic Acid |2 NLM | |
| 650 | 7 | |a 318ADP12RI |2 NLM | |
| 650 | 7 | |a baicalin |2 NLM | |
| 650 | 7 | |a 347Q89U4M5 |2 NLM | |
| 700 | 1 | |a Ni, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Guannan |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Yeli |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Jia |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica |d 1989 |g 35(2010), 24 vom: 01. Dez., Seite 3291-3 |w (DE-627)NLM012733113 |x 1001-5302 |7 nnns |
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