Prevalence of intentional under- and overdosing of insulin in children and adolescents with type 1 diabetes
© 2011 John Wiley & Sons A/S..
OBJECTIVE: The aim of this study was to evaluate the prevalence of insulin under- and overdosing in paediatric patients.
RESEARCH DESIGN AND METHODS: Cross-sectional study including 241 patients (age 14.0 + 2.7 yr, 42.5% males) with type 1 diabetes from 21 diabetic outpatient clinics. Haemoglobin A1c (HbA1c), height, and weight were available from clinical records. Patients were interviewed with the Diabetes Self-Management Profile (DSMP) interview. T test, U test, and chi-squared test were used for comparison.
RESULTS: On the basis of the DSMP, 103 (42.7%) patients (group A) showed adherence to the therapeutic insulin regimen, while 71 (29.5%) patients (group B) confessed intentional over and/or under-dosing of insulin. Sixty-seven (27.8%) adolescents (group C) reported management problems leading to unintended inappropriate insulin dosages. In group B, 55 (22.8%) injected higher insulin doses and 58 (24.1%) omitted insulin. Patients of group B compared to group A were older 15.0 (±2.5) vs. 14.0 (±2.5) yr (p < 0.01), older at onset 9.5 (±3.6) vs. 8.3 (±3.8) yr (p = 0.05), were more often girls (69 vs. 45.6%), had a higher actual HbA1c (8.7 ± 1.7 vs. 7.8 ± 1.2%), and a higher average HbA1c in the previous year (8.3 ± 1.6 vs. 7.9 ± 1.2%) (p < 0.01). No significant differences could be found between group A and group C.
CONCLUSION: Intentional overdosing of insulin is almost as prevalent in children and adolescents as insulin omission. Females are more at risk.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Pediatric diabetes - 12(2011), 7 vom: 08. Nov., Seite 627-31 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Schober, Edith [VerfasserIn] |
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| Links: |
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| Themen: |
Hypoglycemic Agents |
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| Anmerkungen: |
Date Completed 15.03.2012 Date Revised 31.10.2011 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/j.1399-5448.2011.00759.x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM206929242 |
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| 100 | 1 | |a Schober, Edith |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevalence of intentional under- and overdosing of insulin in children and adolescents with type 1 diabetes |
| 264 | 1 | |c 2011 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 15.03.2012 | ||
| 500 | |a Date Revised 31.10.2011 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2011 John Wiley & Sons A/S. | ||
| 520 | |a OBJECTIVE: The aim of this study was to evaluate the prevalence of insulin under- and overdosing in paediatric patients | ||
| 520 | |a RESEARCH DESIGN AND METHODS: Cross-sectional study including 241 patients (age 14.0 + 2.7 yr, 42.5% males) with type 1 diabetes from 21 diabetic outpatient clinics. Haemoglobin A1c (HbA1c), height, and weight were available from clinical records. Patients were interviewed with the Diabetes Self-Management Profile (DSMP) interview. T test, U test, and chi-squared test were used for comparison | ||
| 520 | |a RESULTS: On the basis of the DSMP, 103 (42.7%) patients (group A) showed adherence to the therapeutic insulin regimen, while 71 (29.5%) patients (group B) confessed intentional over and/or under-dosing of insulin. Sixty-seven (27.8%) adolescents (group C) reported management problems leading to unintended inappropriate insulin dosages. In group B, 55 (22.8%) injected higher insulin doses and 58 (24.1%) omitted insulin. Patients of group B compared to group A were older 15.0 (±2.5) vs. 14.0 (±2.5) yr (p < 0.01), older at onset 9.5 (±3.6) vs. 8.3 (±3.8) yr (p = 0.05), were more often girls (69 vs. 45.6%), had a higher actual HbA1c (8.7 ± 1.7 vs. 7.8 ± 1.2%), and a higher average HbA1c in the previous year (8.3 ± 1.6 vs. 7.9 ± 1.2%) (p < 0.01). No significant differences could be found between group A and group C | ||
| 520 | |a CONCLUSION: Intentional overdosing of insulin is almost as prevalent in children and adolescents as insulin omission. Females are more at risk | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Hypoglycemic Agents |2 NLM | |
| 650 | 7 | |a Insulin |2 NLM | |
| 700 | 1 | |a Wagner, Gudrun |e verfasserin |4 aut | |
| 700 | 1 | |a Berger, Gabriele |e verfasserin |4 aut | |
| 700 | 1 | |a Gerber, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Mengl, Marlene |e verfasserin |4 aut | |
| 700 | 1 | |a Sonnenstatter, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Barrientos, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Rami, Birgit |e verfasserin |4 aut | |
| 700 | 1 | |a Karwautz, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Fritsch, Maria |e verfasserin |4 aut | |
| 700 | 0 | |a Austrian Diabetic Incidence Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Bauer, M |e investigator |4 oth | |
| 700 | 1 | |a Zimmerer, F |e investigator |4 oth | |
| 700 | 1 | |a Prchla, C |e investigator |4 oth | |
| 700 | 1 | |a Hofer, S |e investigator |4 oth | |
| 700 | 1 | |a Rojacher, T |e investigator |4 oth | |
| 700 | 1 | |a Kovacic, R |e investigator |4 oth | |
| 700 | 1 | |a Jäger, A |e investigator |4 oth | |
| 700 | 1 | |a Distelberger, G |e investigator |4 oth | |
| 700 | 1 | |a Fussenegger, J |e investigator |4 oth | |
| 700 | 1 | |a Dorninger, L |e investigator |4 oth | |
| 700 | 1 | |a Mühleder, J |e investigator |4 oth | |
| 700 | 1 | |a Wels, K H |e investigator |4 oth | |
| 700 | 1 | |a Kersak, J |e investigator |4 oth | |
| 700 | 1 | |a Wakolbinger, G |e investigator |4 oth | |
| 700 | 1 | |a Ried, K H |e investigator |4 oth | |
| 700 | 1 | |a Bittmann, B |e investigator |4 oth | |
| 700 | 1 | |a Eisenstad, K H |e investigator |4 oth | |
| 700 | 1 | |a Neuhauser, M |e investigator |4 oth | |
| 700 | 1 | |a Kovac, U |e investigator |4 oth | |
| 700 | 1 | |a Judmaier, S |e investigator |4 oth | |
| 700 | 1 | |a Riedl, S |e investigator |4 oth | |
| 700 | 1 | |a Lindauer, S |e investigator |4 oth | |
| 700 | 1 | |a Rath, R |e investigator |4 oth | |
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