The relationship between {beta}-cell function and glycated hemoglobin : results from the veterans administration genetic epidemiology study
OBJECTIVE: The study objective was to assess the relationship between β-cell function and HbA(1c).
RESEARCH DESIGN AND METHODS: A total of 522 Mexican American subjects participated in this study. Each subject received a 75-g oral glucose tolerance test (OGTT) after a 10- to 12-h overnight fast. Insulin sensitivity was assessed with the Matsuda index. Insulin secretory rate was quantitated from deconvolution of the plasma C-peptide concentration. β-Cell function was assessed with the insulin secretion/insulin resistance (IS/IR) (disposition) index and was related to the level of HbA(1c).
RESULTS: At HbA(1c) levels <5.5%, both the Matsuda index of insulin sensitivity and IS/IR index were constant. However, as the HbA(1c) increased >5.5%, there was a precipitous decrease in both the Matsuda index and the IS/IR index. Subjects with HbA(1c) = 6.0-6.4% had a 44 and 74% decrease in the Matsuda index and the IS/IR index, respectively, compared with subjects with HbA(1c) <5.5% (P < 0.01 for both indices). Subjects with normal glucose tolerance and HbA(1c) <5.7% had β-cell function comparable to that of subjects with normal glucose tolerance with HbA(1c) = 5.7-6.4%. However, subjects with impaired fasting glucose or impaired glucose tolerance had a marked decrease in β-cell function independent of their HbA(1c) level.
CONCLUSIONS: The results of the current study demonstrate that in Mexican Americans, as HbA(1c) increases >6.0%, both insulin sensitivity and β-cell function decrease markedly. Performing an OGTT is pivotal for accurate identification of subjects with impaired β-cell function.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Diabetes care - 34(2011), 4 vom: 23. Apr., Seite 1006-10 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kanat, Mustafa [VerfasserIn] |
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| Links: |
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| Themen: |
Glycated Hemoglobin A |
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| Anmerkungen: |
Date Completed 15.07.2011 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.2337/dc10-1352 |
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| funding: |
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|---|---|
| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM206100523 |
|---|
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| 100 | 1 | |a Kanat, Mustafa |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The relationship between {beta}-cell function and glycated hemoglobin |b results from the veterans administration genetic epidemiology study |
| 264 | 1 | |c 2011 | |
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| 500 | |a Date Completed 15.07.2011 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: The study objective was to assess the relationship between β-cell function and HbA(1c) | ||
| 520 | |a RESEARCH DESIGN AND METHODS: A total of 522 Mexican American subjects participated in this study. Each subject received a 75-g oral glucose tolerance test (OGTT) after a 10- to 12-h overnight fast. Insulin sensitivity was assessed with the Matsuda index. Insulin secretory rate was quantitated from deconvolution of the plasma C-peptide concentration. β-Cell function was assessed with the insulin secretion/insulin resistance (IS/IR) (disposition) index and was related to the level of HbA(1c) | ||
| 520 | |a RESULTS: At HbA(1c) levels <5.5%, both the Matsuda index of insulin sensitivity and IS/IR index were constant. However, as the HbA(1c) increased >5.5%, there was a precipitous decrease in both the Matsuda index and the IS/IR index. Subjects with HbA(1c) = 6.0-6.4% had a 44 and 74% decrease in the Matsuda index and the IS/IR index, respectively, compared with subjects with HbA(1c) <5.5% (P < 0.01 for both indices). Subjects with normal glucose tolerance and HbA(1c) <5.7% had β-cell function comparable to that of subjects with normal glucose tolerance with HbA(1c) = 5.7-6.4%. However, subjects with impaired fasting glucose or impaired glucose tolerance had a marked decrease in β-cell function independent of their HbA(1c) level | ||
| 520 | |a CONCLUSIONS: The results of the current study demonstrate that in Mexican Americans, as HbA(1c) increases >6.0%, both insulin sensitivity and β-cell function decrease markedly. Performing an OGTT is pivotal for accurate identification of subjects with impaired β-cell function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Glycated Hemoglobin A |2 NLM | |
| 650 | 7 | |a Insulin |2 NLM | |
| 700 | 1 | |a Winnier, Diedre |e verfasserin |4 aut | |
| 700 | 1 | |a Norton, Luke |e verfasserin |4 aut | |
| 700 | 1 | |a Arar, Nazik |e verfasserin |4 aut | |
| 700 | 1 | |a Jenkinson, Chris |e verfasserin |4 aut | |
| 700 | 1 | |a Defronzo, Ralph A |e verfasserin |4 aut | |
| 700 | 1 | |a Abdul-Ghani, Muhammad A |e verfasserin |4 aut | |
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