Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status--the Japan Public Health Center-based Prospective Study
Copyright © 2011 Elsevier Inc. All rights reserved..
OBJECTIVE: The study aims to investigate the association between leisure-time physical activity and breast cancer risk in consideration of tumor estrogen-receptor/progesterone-receptor status.
METHODS: We conducted a population-based prospective cohort study among 53,578 women in the Japan Public Health Center-based Prospective Study. Leisure-time physical activity was assessed by self-reported questionnaires. A Cox proportional hazards regression model was used to derive relative risks and 95% confidence intervals.
RESULTS: From 1990-1993 to the end of 2007, 652 cases were identified. The breast cancer rates (per 100,000 person-years) in the sedentary groups (≤3 days/month) was 84 in overall, 97 in premenopausal and 75 in postmenopausal women. We observed a statistically significant inverse association between leisure-time physical activity and breast cancer risk (relative risk(≥3 days/week vs. ≤3 days/month)=0.73; 95% confidence interval 0.54-1.00; p(trend) 0.037), particularly in estrogen receptor+progesterone receptor+ (relative risk 0.43; 0.19-1.00; p(trend) 0.022), and this inverse trend was apparent among postmenopausal women (relative risk 0.25; 0.06-1.06; p(trend) 0.041). An inverse trend was also observed between daily total physical activity and postmenopausal estrogen receptor+progesterone receptor+ risk (p=0.046). Among body mass index ≥25 kg/m(2) group, leisure-time physical activity was associated with decreased risk (relative risk(≥1 day/week vs. ≤3 days/month)=0.65; 0.43-0.97; p(trend) 0.033).
CONCLUSION: Active participation in leisure-time physical activity may contribute to a decrease in breast cancer risk, particularly for postmenopausal estrogen receptor+progesterone receptor+ tumors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Preventive medicine - 52(2011), 3-4 vom: 01. März, Seite 227-33 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suzuki, Reiko [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers, Tumor |
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| Anmerkungen: |
Date Completed 15.07.2011 Date Revised 19.11.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ypmed.2011.01.016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM205615503 |
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| 041 | |a eng | ||
| 100 | 1 | |a Suzuki, Reiko |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status--the Japan Public Health Center-based Prospective Study |
| 264 | 1 | |c 2011 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.07.2011 | ||
| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2011 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: The study aims to investigate the association between leisure-time physical activity and breast cancer risk in consideration of tumor estrogen-receptor/progesterone-receptor status | ||
| 520 | |a METHODS: We conducted a population-based prospective cohort study among 53,578 women in the Japan Public Health Center-based Prospective Study. Leisure-time physical activity was assessed by self-reported questionnaires. A Cox proportional hazards regression model was used to derive relative risks and 95% confidence intervals | ||
| 520 | |a RESULTS: From 1990-1993 to the end of 2007, 652 cases were identified. The breast cancer rates (per 100,000 person-years) in the sedentary groups (≤3 days/month) was 84 in overall, 97 in premenopausal and 75 in postmenopausal women. We observed a statistically significant inverse association between leisure-time physical activity and breast cancer risk (relative risk(≥3 days/week vs. ≤3 days/month)=0.73; 95% confidence interval 0.54-1.00; p(trend) 0.037), particularly in estrogen receptor+progesterone receptor+ (relative risk 0.43; 0.19-1.00; p(trend) 0.022), and this inverse trend was apparent among postmenopausal women (relative risk 0.25; 0.06-1.06; p(trend) 0.041). An inverse trend was also observed between daily total physical activity and postmenopausal estrogen receptor+progesterone receptor+ risk (p=0.046). Among body mass index ≥25 kg/m(2) group, leisure-time physical activity was associated with decreased risk (relative risk(≥1 day/week vs. ≤3 days/month)=0.65; 0.43-0.97; p(trend) 0.033) | ||
| 520 | |a CONCLUSION: Active participation in leisure-time physical activity may contribute to a decrease in breast cancer risk, particularly for postmenopausal estrogen receptor+progesterone receptor+ tumors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 650 | 7 | |a Receptors, Estrogen |2 NLM | |
| 650 | 7 | |a Receptors, Progesterone |2 NLM | |
| 700 | 1 | |a Iwasaki, Motoki |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Seiichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Manami |e verfasserin |4 aut | |
| 700 | 1 | |a Sasazuki, Shizuka |e verfasserin |4 aut | |
| 700 | 1 | |a Sawada, Norie |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaji, Taiki |e verfasserin |4 aut | |
| 700 | 1 | |a Shimazu, Taichi |e verfasserin |4 aut | |
| 700 | 1 | |a Tsugane, Shoichiro |e verfasserin |4 aut | |
| 700 | 0 | |a Japan Public Health Center-based Prospective Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Tsugane, S |e investigator |4 oth | |
| 700 | 1 | |a Inoue, M |e investigator |4 oth | |
| 700 | 1 | |a Sobue, T |e investigator |4 oth | |
| 700 | 1 | |a Hanaoka, T |e investigator |4 oth | |
| 700 | 1 | |a Ogata, J |e investigator |4 oth | |
| 700 | 1 | |a Baba, S |e investigator |4 oth | |
| 700 | 1 | |a Mannami, T |e investigator |4 oth | |
| 700 | 1 | |a Okayama, A |e investigator |4 oth | |
| 700 | 1 | |a Kokubo, Y |e investigator |4 oth | |
| 700 | 1 | |a Miyakawa, K |e investigator |4 oth | |
| 700 | 1 | |a Saito, F |e investigator |4 oth | |
| 700 | 1 | |a Koizumi, A |e investigator |4 oth | |
| 700 | 1 | |a Sano, Y |e investigator |4 oth | |
| 700 | 1 | |a Hashimoto, I |e investigator |4 oth | |
| 700 | 1 | |a Ikuta, T |e investigator |4 oth | |
| 700 | 1 | |a Miyajima, Y |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, N |e investigator |4 oth | |
| 700 | 1 | |a Nagasawa, S |e investigator |4 oth | |
| 700 | 1 | |a Furusugi, Y |e investigator |4 oth | |
| 700 | 1 | |a Nagai, N |e investigator |4 oth | |
| 700 | 1 | |a Sanada, H |e investigator |4 oth | |
| 700 | 1 | |a Hatayama, Y |e investigator |4 oth | |
| 700 | 1 | |a Kobayashi, F |e investigator |4 oth | |
| 700 | 1 | |a Uchino, H |e investigator |4 oth | |
| 700 | 1 | |a Shirai, Y |e investigator |4 oth | |
| 700 | 1 | |a Kondo, T |e investigator |4 oth | |
| 700 | 1 | |a Sasaki, R |e investigator |4 oth | |
| 700 | 1 | |a Watanabe, Y |e investigator |4 oth | |
| 700 | 1 | |a Miyagawa, Y |e investigator |4 oth | |
| 700 | 1 | |a Kobayashi, Y |e investigator |4 oth | |
| 700 | 1 | |a Kishimoto, Y |e investigator |4 oth | |
| 700 | 1 | |a Takara, E |e investigator |4 oth | |
| 700 | 1 | |a Fukuyama, T |e investigator |4 oth | |
| 700 | 1 | |a Kinjo, M |e investigator |4 oth | |
| 700 | 1 | |a Irei, M |e investigator |4 oth | |
| 700 | 1 | |a Sakiyama, H |e investigator |4 oth | |
| 700 | 1 | |a Imoto, K |e investigator |4 oth | |
| 700 | 1 | |a Yazawa, H |e investigator |4 oth | |
| 700 | 1 | |a Seo, T |e investigator |4 oth | |
| 700 | 1 | |a Seiko, A |e investigator |4 oth | |
| 700 | 1 | |a Ito, F |e investigator |4 oth | |
| 700 | 1 | |a Shoji, F |e investigator |4 oth | |
| 700 | 1 | |a Murata, A |e investigator |4 oth | |
| 700 | 1 | |a Minato, K |e investigator |4 oth | |
| 700 | 1 | |a Motegi, K |e investigator |4 oth | |
| 700 | 1 | |a Fujieda, T |e investigator |4 oth | |
| 700 | 1 | |a Matsui, K |e investigator |4 oth | |
| 700 | 1 | |a Abe, T |e investigator |4 oth | |
| 700 | 1 | |a Katagiri, M |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, M |e investigator |4 oth | |
| 700 | 1 | |a Doi, M |e investigator |4 oth | |
| 700 | 1 | |a Terao, A |e investigator |4 oth | |
| 700 | 1 | |a Ishikawa, Y |e investigator |4 oth | |
| 700 | 1 | |a Tagami, T |e investigator |4 oth | |
| 700 | 1 | |a Sueta, H |e investigator |4 oth | |
| 700 | 1 | |a Doi, H |e investigator |4 oth | |
| 700 | 1 | |a Urata, M |e investigator |4 oth | |
| 700 | 1 | |a Okamoto, N |e investigator |4 oth | |
| 700 | 1 | |a Ide, F |e investigator |4 oth | |
| 700 | 1 | |a Sakiyama, H |e investigator |4 oth | |
| 700 | 1 | |a Onga, N |e investigator |4 oth | |
| 700 | 1 | |a Takaesu, H |e investigator |4 oth | |
| 700 | 1 | |a Uehara, M |e investigator |4 oth | |
| 700 | 1 | |a Horii, F |e investigator |4 oth | |
| 700 | 1 | |a Asano, I |e investigator |4 oth | |
| 700 | 1 | |a Yamaguchi, H |e investigator |4 oth | |
| 700 | 1 | |a Aoki, K |e investigator |4 oth | |
| 700 | 1 | |a Maruyama, S |e investigator |4 oth | |
| 700 | 1 | |a Ichii, M |e investigator |4 oth | |
| 700 | 1 | |a Takano, M |e investigator |4 oth | |
| 700 | 1 | |a Matsushima, S |e investigator |4 oth | |
| 700 | 1 | |a Natsukawa, S |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, K |e investigator |4 oth | |
| 700 | 1 | |a Kabuto, M |e investigator |4 oth | |
| 700 | 1 | |a Yamaguchi, M |e investigator |4 oth | |
| 700 | 1 | |a Matsumura, Y |e investigator |4 oth | |
| 700 | 1 | |a Sasaki, S |e investigator |4 oth | |
| 700 | 1 | |a Watanabe, S |e investigator |4 oth | |
| 700 | 1 | |a Noda, M |e investigator |4 oth | |
| 700 | 1 | |a Tominaga, S |e investigator |4 oth | |
| 700 | 1 | |a Shimizu, H |e investigator |4 oth | |
| 700 | 1 | |a Iida, M |e investigator |4 oth | |
| 700 | 1 | |a Ajiki, W |e investigator |4 oth | |
| 700 | 1 | |a Ioka, A |e investigator |4 oth | |
| 700 | 1 | |a Sato, S |e investigator |4 oth | |
| 700 | 1 | |a Tsubono, Y |e investigator |4 oth | |
| 700 | 1 | |a Nakamura, K |e investigator |4 oth | |
| 700 | 1 | |a Honda, Y |e investigator |4 oth | |
| 700 | 1 | |a Yamagishi, K |e investigator |4 oth | |
| 700 | 1 | |a Sakurai, S |e investigator |4 oth | |
| 700 | 1 | |a Akabane, M |e investigator |4 oth | |
| 700 | 1 | |a Kadowaki, T |e investigator |4 oth | |
| 700 | 1 | |a Kawaguchi, Y |e investigator |4 oth | |
| 700 | 1 | |a Takashima, Y |e investigator |4 oth | |
| 700 | 1 | |a Sugimura, H |e investigator |4 oth | |
| 700 | 1 | |a Iso, H |e investigator |4 oth | |
| 700 | 1 | |a Maruyama, E |e investigator |4 oth | |
| 700 | 1 | |a Konishi, M |e investigator |4 oth | |
| 700 | 1 | |a Okada, K |e investigator |4 oth | |
| 700 | 1 | |a Saito, I |e investigator |4 oth | |
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