The human microbiome in multiple sclerosis : pathogenic or protective constituents?
The human microbiome is comprised of commensal and pathogenic microorganisms, which exert diverse effects in close proximity to the site of intection as well as in remote tissues through immune-mediated mechanisms. Multiple infectious agents have been implicated in the pathogenesis of multiple sclerosis (MS) with variable findings depending on the agent, techniques, and disease phenotype. Herein, the contributions of individual infectious agents to MS and their effects on the immune and nervous systems are reviewed, focusing on herpes viruses, coronaviruses, retroviruses, and synchronic infections. While infectious agents are often assumed to be pathogenic, their effects might also be beneficial to the host in the long-term, depending on age and the type of immunogen/pathogen exposure, as proposed by the hygiene hypothesis. The human microbiome has potential impact on future diagnostic and therapeutic issues in MS.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 Suppl 2 |
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| Enthalten in: |
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 37 Suppl 2(2010) vom: 06. Sept., Seite S24-33 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Power, Christopher [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 08.02.2011 Date Revised 02.09.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM205171354 |
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| 100 | 1 | |a Power, Christopher |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The human microbiome in multiple sclerosis |b pathogenic or protective constituents? |
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| 500 | |a Date Revised 02.09.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The human microbiome is comprised of commensal and pathogenic microorganisms, which exert diverse effects in close proximity to the site of intection as well as in remote tissues through immune-mediated mechanisms. Multiple infectious agents have been implicated in the pathogenesis of multiple sclerosis (MS) with variable findings depending on the agent, techniques, and disease phenotype. Herein, the contributions of individual infectious agents to MS and their effects on the immune and nervous systems are reviewed, focusing on herpes viruses, coronaviruses, retroviruses, and synchronic infections. While infectious agents are often assumed to be pathogenic, their effects might also be beneficial to the host in the long-term, depending on age and the type of immunogen/pathogen exposure, as proposed by the hygiene hypothesis. The human microbiome has potential impact on future diagnostic and therapeutic issues in MS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Antony, Joseph M |e verfasserin |4 aut | |
| 700 | 1 | |a Ellestad, Kristofor K |e verfasserin |4 aut | |
| 700 | 1 | |a Deslauriers, André |e verfasserin |4 aut | |
| 700 | 1 | |a Bhat, Rakesh |e verfasserin |4 aut | |
| 700 | 1 | |a Noorbakhsh, Farshid |e verfasserin |4 aut | |
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