Distributions of primary nasopharyngeal carcinoma tumor and patterns of skull base erosion detected by magnetic resonance imaging
OBJECTIVE: To evaluate the distributions of primary nasopharyngeal carcinoma (NPC) and the patterns of skull base involvement in NPC patients using magnetic resonance imaging (MRI).
METHODS: After the approval of institutional review board and informed consent, 838 consecutive newly-diagnosed and untreated NPC patients were examined by MRI. Their MR images were reviewed by two independent radiologists.
RESULTS: Among all cases, the incidence rates of superior side and post-superior side involvement were 98.57% (826/838) and 98.21% (823/838) respectively. The differences were not significant between these two sides (P > 0.05). Lateral side erosion was demonstrated in 784 (93.56%) cases. Posterior side was involved in 391 (46.66%) cases. The total incidence rate of skull base involvement was 65.51% (549/838). According to the anatomic site, the pathways of skull base involvement were classified into 5 spreading routes: anterior; superior; super-lateral; super-anterior and super-posterior. According to the incidence rates and the results of chi-square test, the anatomic sites around the nasopharynx were classified into three groups of risk grades: high-risk (≥ 35%), medium-risk (≥ 5% - 35%) and low-risk (< 5%).
CONCLUSION: Skull base involvement of NPC spreads stepwise from proximal site to more distal sites. The area of skull base involvement in NPC is classified into high-grade, medium-grade and lower-grade groups respectively. The high and medium-grade groups are related with T3 stage while the lower-grade group T4 stage. Thus T3 stage should be subdivided into T3a and T3b. These schemes may be useful in a more accurate NPC staging and a delineation of clinical target volume for radiotherapy in NPC patients.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:90 |
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| Enthalten in: |
Zhonghua yi xue za zhi - 90(2010), 47 vom: 21. Dez., Seite 3347-50 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Li, Yi-Zhuo [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 15.09.2011 Date Revised 25.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM204953235 |
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| 100 | 1 | |a Li, Yi-Zhuo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Distributions of primary nasopharyngeal carcinoma tumor and patterns of skull base erosion detected by magnetic resonance imaging |
| 264 | 1 | |c 2010 | |
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| 500 | |a Date Completed 15.09.2011 | ||
| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To evaluate the distributions of primary nasopharyngeal carcinoma (NPC) and the patterns of skull base involvement in NPC patients using magnetic resonance imaging (MRI) | ||
| 520 | |a METHODS: After the approval of institutional review board and informed consent, 838 consecutive newly-diagnosed and untreated NPC patients were examined by MRI. Their MR images were reviewed by two independent radiologists | ||
| 520 | |a RESULTS: Among all cases, the incidence rates of superior side and post-superior side involvement were 98.57% (826/838) and 98.21% (823/838) respectively. The differences were not significant between these two sides (P > 0.05). Lateral side erosion was demonstrated in 784 (93.56%) cases. Posterior side was involved in 391 (46.66%) cases. The total incidence rate of skull base involvement was 65.51% (549/838). According to the anatomic site, the pathways of skull base involvement were classified into 5 spreading routes: anterior; superior; super-lateral; super-anterior and super-posterior. According to the incidence rates and the results of chi-square test, the anatomic sites around the nasopharynx were classified into three groups of risk grades: high-risk (≥ 35%), medium-risk (≥ 5% - 35%) and low-risk (< 5%) | ||
| 520 | |a CONCLUSION: Skull base involvement of NPC spreads stepwise from proximal site to more distal sites. The area of skull base involvement in NPC is classified into high-grade, medium-grade and lower-grade groups respectively. The high and medium-grade groups are related with T3 stage while the lower-grade group T4 stage. Thus T3 stage should be subdivided into T3a and T3b. These schemes may be useful in a more accurate NPC staging and a delineation of clinical target volume for radiotherapy in NPC patients | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Wu, Pei-Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Zi-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Chuan-Miao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Guo-Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Ci-Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Pei-Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xue-Wen |e verfasserin |4 aut | |
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