Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure
Copyright © 2010 Mosby, Inc. All rights reserved..
BACKGROUND: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure.
METHODS: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width.
RESULTS: Anemia (hemoglobin≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P=.032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P=.008).
CONCLUSIONS: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:160 |
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| Enthalten in: |
American heart journal - 160(2010), 6 vom: 01. Dez., Seite 1142-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Adams, Kirkwood F [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 08.02.2011 Date Revised 19.11.2015 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.ahj.2010.07.033 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM204248388 |
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| 100 | 1 | |a Adams, Kirkwood F |c Jr |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure |
| 264 | 1 | |c 2010 | |
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| 500 | |a Date Completed 08.02.2011 | ||
| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2010 Mosby, Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure | ||
| 520 | |a METHODS: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width | ||
| 520 | |a RESULTS: Anemia (hemoglobin≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P=.032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P=.008) | ||
| 520 | |a CONCLUSIONS: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Troponin T |2 NLM | |
| 700 | 1 | |a Mehra, Mandeep R |e verfasserin |4 aut | |
| 700 | 1 | |a Oren, Ron M |e verfasserin |4 aut | |
| 700 | 1 | |a O'Connor, Christopher M |e verfasserin |4 aut | |
| 700 | 1 | |a Chiong, Jun R |e verfasserin |4 aut | |
| 700 | 1 | |a Ghali, Jalal K |e verfasserin |4 aut | |
| 700 | 1 | |a Lenihan, Daniel J |e verfasserin |4 aut | |
| 700 | 1 | |a Dunlap, Stephanie H |e verfasserin |4 aut | |
| 700 | 1 | |a Patterson, J Herbert |e verfasserin |4 aut | |
| 700 | 1 | |a Schwartz, Todd A |e verfasserin |4 aut | |
| 700 | 1 | |a Felker, G Michael |e verfasserin |4 aut | |
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