A novel drug and gene co-delivery system based on Poly(epsilon-caprolactone)-Poly(ethylene glycol)-Poly(epsilon-caprolactone) grafted polyethyleneimine micelle
In this paper, we prepared a novel cationic self-assembled micelle from poly(epsilon-caprolactone)-poly(ethyl glycol)-poly(epsilon-caprolactone) grafted polyethyleneimine (PCEC-g-PEI). The PCEC-g-PEI micelles, formed by self-assembly method, had mean particle size of ca. 82 nm and zeta potential of +22.5 mV at 37 degrees C, and could efficiently transfer pGFP into HEK293 cells in vitro. Meanwhile, as a model hydrophobic chemotherapeutic drug, honokiol was loaded into PCEC-g-PEI micelles by direct dissolution method assisted by ultrasonication. The honokiol loaded cationic PCEC-g-PEI micelles could effectively adsorb DNA onto its surface, while it could release honokiol in an extended period in vitro. This study demonstrated a novel DNA and hydrophobic chemotherapeutic drug co-delivery system.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Journal of nanoscience and nanotechnology - 10(2010), 12 vom: 01. Dez., Seite 7958-64 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Men, Ke [VerfasserIn] |
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| Anmerkungen: |
Date Completed 30.12.2010 Date Revised 15.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM204010551 |
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| 100 | 1 | |a Men, Ke |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A novel drug and gene co-delivery system based on Poly(epsilon-caprolactone)-Poly(ethylene glycol)-Poly(epsilon-caprolactone) grafted polyethyleneimine micelle |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
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| 500 | |a Date Completed 30.12.2010 | ||
| 500 | |a Date Revised 15.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In this paper, we prepared a novel cationic self-assembled micelle from poly(epsilon-caprolactone)-poly(ethyl glycol)-poly(epsilon-caprolactone) grafted polyethyleneimine (PCEC-g-PEI). The PCEC-g-PEI micelles, formed by self-assembly method, had mean particle size of ca. 82 nm and zeta potential of +22.5 mV at 37 degrees C, and could efficiently transfer pGFP into HEK293 cells in vitro. Meanwhile, as a model hydrophobic chemotherapeutic drug, honokiol was loaded into PCEC-g-PEI micelles by direct dissolution method assisted by ultrasonication. The honokiol loaded cationic PCEC-g-PEI micelles could effectively adsorb DNA onto its surface, while it could release honokiol in an extended period in vitro. This study demonstrated a novel DNA and hydrophobic chemotherapeutic drug co-delivery system | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Biphenyl Compounds |2 NLM | |
| 650 | 7 | |a Lignans |2 NLM | |
| 650 | 7 | |a Micelles |2 NLM | |
| 650 | 7 | |a Nanoconjugates |2 NLM | |
| 650 | 7 | |a Polyesters |2 NLM | |
| 650 | 7 | |a poly(epsilon-caprolactone)-poly(oxyethylene)-poly(epsilon-caprolactone) |2 NLM | |
| 650 | 7 | |a honokiol |2 NLM | |
| 650 | 7 | |a 11513CCO0N |2 NLM | |
| 650 | 7 | |a Polyethylene Glycols |2 NLM | |
| 650 | 7 | |a 3WJQ0SDW1A |2 NLM | |
| 650 | 7 | |a Polyethyleneimine |2 NLM | |
| 650 | 7 | |a 9002-98-6 |2 NLM | |
| 650 | 7 | |a DNA |2 NLM | |
| 650 | 7 | |a 9007-49-2 |2 NLM | |
| 700 | 1 | |a Gou, Ma Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Qing Fa |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiu Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Shuai |e verfasserin |4 aut | |
| 700 | 1 | |a Kan, Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Mei Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Li Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, Zhi Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Shu Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Yu Quan |e verfasserin |4 aut | |
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