Association between the malnutrition-inflammation score and post-transplant anaemia
BACKGROUND: Post-transplant anaemia (PTA) is common and is associated with adverse consequences. The protein-energy wasting (PEW) syndrome is associated with erythropoietin resistance in patients on maintenance dialysis. We assessed the association between PEW and PTA in a large prevalent cohort of stable kidney-transplanted patients.
METHODS: Data from 942 prevalent kidney-transplanted patients were analysed. Socio-demographic parameters, laboratory results, transplantation-related data and medication were obtained from the charts. Biomarkers reflecting nutritional status and inflammation [serum leptin, albumin, interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) and C-reactive protein] were measured. Anthropometric measures and the malnutrition-inflammation score (MIS) were also tabulated. Anaemia was defined according to the guidelines of the American Society of Transplantation.
RESULTS: Mean age was 51 ± 13 years, 57% were males and 22% had diabetes. The prevalence of PTA was 33%. The haemoglobin (Hb) level significantly and negatively correlated with the MIS (rho = - 0.316), marginally with serum TNF-α (rho = - 0.079) and serum IL-6 (rho = - 0.075) and positively with serum transferrin (r = 0.298), serum albumin (r = 0.274), abdominal circumference (r = 0.254) and serum leptin (rho = - 0.152), P < 0.05 for all. In a multivariable linear regression model, MIS was independently associated with Hb (beta = - 0.118, P = 0.004) in patients with estimated glomerular filtration rate (eGFR) lower than or equal to 60 mL/min/1.73 m(2), but not in patients with higher eGFR.
CONCLUSIONS: The MIS is independently associated with PTA in the kidney-transplanted population with eGFR lower than or equal to 60 mL/min/1.73 m(2).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 26(2011), 6 vom: 01. Juni, Seite 2000-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Molnar, Miklos Z [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 30.09.2011 Date Revised 06.06.2011 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1093/ndt/gfq690 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM203960068 |
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| 100 | 1 | |a Molnar, Miklos Z |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between the malnutrition-inflammation score and post-transplant anaemia |
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| 500 | |a Date Revised 06.06.2011 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Post-transplant anaemia (PTA) is common and is associated with adverse consequences. The protein-energy wasting (PEW) syndrome is associated with erythropoietin resistance in patients on maintenance dialysis. We assessed the association between PEW and PTA in a large prevalent cohort of stable kidney-transplanted patients | ||
| 520 | |a METHODS: Data from 942 prevalent kidney-transplanted patients were analysed. Socio-demographic parameters, laboratory results, transplantation-related data and medication were obtained from the charts. Biomarkers reflecting nutritional status and inflammation [serum leptin, albumin, interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) and C-reactive protein] were measured. Anthropometric measures and the malnutrition-inflammation score (MIS) were also tabulated. Anaemia was defined according to the guidelines of the American Society of Transplantation | ||
| 520 | |a RESULTS: Mean age was 51 ± 13 years, 57% were males and 22% had diabetes. The prevalence of PTA was 33%. The haemoglobin (Hb) level significantly and negatively correlated with the MIS (rho = - 0.316), marginally with serum TNF-α (rho = - 0.079) and serum IL-6 (rho = - 0.075) and positively with serum transferrin (r = 0.298), serum albumin (r = 0.274), abdominal circumference (r = 0.254) and serum leptin (rho = - 0.152), P < 0.05 for all. In a multivariable linear regression model, MIS was independently associated with Hb (beta = - 0.118, P = 0.004) in patients with estimated glomerular filtration rate (eGFR) lower than or equal to 60 mL/min/1.73 m(2), but not in patients with higher eGFR | ||
| 520 | |a CONCLUSIONS: The MIS is independently associated with PTA in the kidney-transplanted population with eGFR lower than or equal to 60 mL/min/1.73 m(2) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 700 | 1 | |a Czira, Maria E |e verfasserin |4 aut | |
| 700 | 1 | |a Rudas, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Ujszaszi, Akos |e verfasserin |4 aut | |
| 700 | 1 | |a Haromszeki, Bela |e verfasserin |4 aut | |
| 700 | 1 | |a Kosa, Janos P |e verfasserin |4 aut | |
| 700 | 1 | |a Lakatos, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Beko, Gabriella |e verfasserin |4 aut | |
| 700 | 1 | |a Sarvary, Eniko |e verfasserin |4 aut | |
| 700 | 1 | |a Varga, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Fornadi, Katalin |e verfasserin |4 aut | |
| 700 | 1 | |a Novak, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Rosivall, Laszlo |e verfasserin |4 aut | |
| 700 | 1 | |a Kiss, Istvan |e verfasserin |4 aut | |
| 700 | 1 | |a Remport, Adam |e verfasserin |4 aut | |
| 700 | 1 | |a Goldsmith, David J |e verfasserin |4 aut | |
| 700 | 1 | |a Kovesdy, Csaba P |e verfasserin |4 aut | |
| 700 | 1 | |a Mucsi, Istvan |e verfasserin |4 aut | |
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