Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment experienced patients
Etravirine is an enzyme inducer and could lower the concentration of combined drugs. Ten HIV-1-infected patients with multiple treatment failure received raltegravir (400 mg, twice daily) and darunavir/ritonavir (600/100 mg, twice daily). Addition of etravirine (200 mg, twice daily) leads to a significant increase in raltegravir and darunavir trough concentrations (405 vs. 118 and 3837 vs. 2241 ng/ml) and darunavir area under the curve (AUC(12h)) (50 083 vs. 36 277 ng h/ml). All pharmacokinetic parameters appeared to be highly variable regardless to the addition of etravirine.
| Errataetall: |
CommentIn: AIDS. 2011 Apr 24;25(7):1012-3; author reply 1011-2. - PMID 21412129 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
AIDS (London, England) - 24(2010), 16 vom: 23. Okt., Seite 2581-3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Barrail-Tran, Aurélie [VerfasserIn] |
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| Themen: |
0C50HW4FO1 |
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| Anmerkungen: |
Date Completed 25.03.2011 Date Revised 09.12.2020 published: Print CommentIn: AIDS. 2011 Apr 24;25(7):1012-3; author reply 1011-2. - PMID 21412129 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM202508080 |
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| 245 | 1 | 0 | |a Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment experienced patients |
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| 500 | |a CommentIn: AIDS. 2011 Apr 24;25(7):1012-3; author reply 1011-2. - PMID 21412129 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Etravirine is an enzyme inducer and could lower the concentration of combined drugs. Ten HIV-1-infected patients with multiple treatment failure received raltegravir (400 mg, twice daily) and darunavir/ritonavir (600/100 mg, twice daily). Addition of etravirine (200 mg, twice daily) leads to a significant increase in raltegravir and darunavir trough concentrations (405 vs. 118 and 3837 vs. 2241 ng/ml) and darunavir area under the curve (AUC(12h)) (50 083 vs. 36 277 ng h/ml). All pharmacokinetic parameters appeared to be highly variable regardless to the addition of etravirine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Drug Combinations |2 NLM | |
| 650 | 7 | |a HIV Protease Inhibitors |2 NLM | |
| 650 | 7 | |a Nitriles |2 NLM | |
| 650 | 7 | |a Pyridazines |2 NLM | |
| 650 | 7 | |a Pyrimidines |2 NLM | |
| 650 | 7 | |a Sulfonamides |2 NLM | |
| 650 | 7 | |a etravirine |2 NLM | |
| 650 | 7 | |a 0C50HW4FO1 |2 NLM | |
| 650 | 7 | |a Ritonavir |2 NLM | |
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| 650 | 7 | |a Darunavir |2 NLM | |
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| 700 | 1 | |a Chêne, Geneviève |e verfasserin |4 aut | |
| 700 | 1 | |a Colin, Céline |e verfasserin |4 aut | |
| 700 | 1 | |a Piketty, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Bollens, Diane |e verfasserin |4 aut | |
| 700 | 1 | |a Katlama, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Descamps, Diane |e verfasserin |4 aut | |
| 700 | 1 | |a Molina, Jean-Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Fagard, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Taburet, Anne-Marie |e verfasserin |4 aut | |
| 700 | 0 | |a ANRS 139 study group |e verfasserin |4 aut | |
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