Update : prolonged-release torasemide
Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved..
Chronic heart failure (CHF) is the cause of significant morbimortality all over the world and its incidence and prevalence are increasing. Fluid retention and volume overload are responsible of large part of morbility related to heart failure. There are a variety of therapy options for CHF, but loop diuretics play an essential role. Furosemide is the most commonly used loop diuretic. Torasemide is a loop diuretic belonging to the pyridine sulfonylurea class. It is a high-ceiling diuretic that has a longer half-life, longer duration of action and higher bioavailability compared to furosemide. It has additional actions such as antialdosterone and vasodilatation effects. It is the only loop diuretic for which it has been shown to effectively lower high blood pressure even with low doses. Thus, torasemide is recommended for CHF treatment instead of furosemide. Clinical trials have indicated that torasemide improves left ventricular function, reduces mortality as well as the frequency and duration of heart failure-related hospitalization. It also increases exercise tolerance, improves New York Heart Association functional classification and quality of life in patients with CHF. In addition, torasemide is a very safe drug. In a postmarketing surveillance study (TORIC) of 1,377 patients with CHF, torasemide significantly reduced cardiovascular mortality in comparison to furosemide. Torasemide reversed myocardial fibrosis and reduced collagen type I synthesis, improving cardiac remodeling in patients with CHF. Torasemide prolonged-release (PR) is a new formulation that, compared with torasemide immediate-release, has a similar systemic exposure but significantly slower rates of absorption and lower fluctuations in plasma concentrations. Its natriuretic efficiency is higher and diuresis is more constant, with a better tolerability.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2010 |
|---|---|
| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 Suppl E |
|---|---|
| Enthalten in: |
Drugs of today (Barcelona, Spain : 1998) - 46 Suppl E(2010) vom: 01. Juli, Seite 1-15 |
| Sprache: |
Spanisch |
|---|
| Weiterer Titel: |
Actualización: torasemida de liberación prolongada |
|---|
| Beteiligte Personen: |
Acuña, Carmen [VerfasserIn] |
|---|
| Themen: |
7LXU5N7ZO5 |
|---|
| Anmerkungen: |
Date Completed 29.10.2010 Date Revised 01.12.2018 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM20195138X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM20195138X | ||
| 003 | DE-627 | ||
| 005 | 20231223223412.0 | ||
| 007 | tu | ||
| 008 | 231223s2010 xx ||||| 00| ||spa c | ||
| 028 | 5 | 2 | |a pubmed24n0673.xml |
| 035 | |a (DE-627)NLM20195138X | ||
| 035 | |a (NLM)20882198 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a spa | ||
| 100 | 1 | |a Acuña, Carmen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Update |b prolonged-release torasemide |
| 246 | 3 | 3 | |a Actualización: torasemida de liberación prolongada |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 29.10.2010 | ||
| 500 | |a Date Revised 01.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved. | ||
| 520 | |a Chronic heart failure (CHF) is the cause of significant morbimortality all over the world and its incidence and prevalence are increasing. Fluid retention and volume overload are responsible of large part of morbility related to heart failure. There are a variety of therapy options for CHF, but loop diuretics play an essential role. Furosemide is the most commonly used loop diuretic. Torasemide is a loop diuretic belonging to the pyridine sulfonylurea class. It is a high-ceiling diuretic that has a longer half-life, longer duration of action and higher bioavailability compared to furosemide. It has additional actions such as antialdosterone and vasodilatation effects. It is the only loop diuretic for which it has been shown to effectively lower high blood pressure even with low doses. Thus, torasemide is recommended for CHF treatment instead of furosemide. Clinical trials have indicated that torasemide improves left ventricular function, reduces mortality as well as the frequency and duration of heart failure-related hospitalization. It also increases exercise tolerance, improves New York Heart Association functional classification and quality of life in patients with CHF. In addition, torasemide is a very safe drug. In a postmarketing surveillance study (TORIC) of 1,377 patients with CHF, torasemide significantly reduced cardiovascular mortality in comparison to furosemide. Torasemide reversed myocardial fibrosis and reduced collagen type I synthesis, improving cardiac remodeling in patients with CHF. Torasemide prolonged-release (PR) is a new formulation that, compared with torasemide immediate-release, has a similar systemic exposure but significantly slower rates of absorption and lower fluctuations in plasma concentrations. Its natriuretic efficiency is higher and diuresis is more constant, with a better tolerability | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Delayed-Action Preparations |2 NLM | |
| 650 | 7 | |a Diuretics |2 NLM | |
| 650 | 7 | |a Sulfonamides |2 NLM | |
| 650 | 7 | |a Furosemide |2 NLM | |
| 650 | 7 | |a 7LXU5N7ZO5 |2 NLM | |
| 650 | 7 | |a Torsemide |2 NLM | |
| 650 | 7 | |a W31X2H97FB |2 NLM | |
| 773 | 0 | 8 | |i Enthalten in |t Drugs of today (Barcelona, Spain : 1998) |d 1998 |g 46 Suppl E(2010) vom: 01. Juli, Seite 1-15 |w (DE-627)NLM123139600 |x 1699-3993 |7 nnns |
| 773 | 1 | 8 | |g volume:46 Suppl E |g year:2010 |g day:01 |g month:07 |g pages:1-15 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 46 Suppl E |j 2010 |b 01 |c 07 |h 1-15 | ||