Determinants of early radiographic progression in ankylosing spondylitis
OBJECTIVE: To investigate the demographic and clinical characteristics associated with early, extensive radiographic changes in ankylosing spondylitis (AS).
METHODS: Radiographic severity was assessed cross-sectionally in 235 patients with AS using the Bath AS Radiological Index spine score (BASRI-s). Patients with extensive radiographic changes on the lumbar portion of BASRI-s were defined as the early axial ankylosis (EAA) Group. ANCOVA and logistic regression analyses were used to identify factors affecting EAA.
RESULTS: Most study patients were men (139/235, 59.0%). Mean disease duration was 12.4 ± 9.3 years. Fifteen percent of women and 34.8% of men with AS were in the EAA group. HLA-B27-positive men with AS had significantly higher BASRI-lumbar scores, while HLA-B27 had no effect on radiographic progression of axial disease in women with AS. Peripheral joint involvement was associated with slow radiographic progression. Hip involvement had no effect on axial progression but uveitis was more frequent in the male EAA group. The odds for an HLA-B27-positive male patient with AS who did not have peripheral arthritis of having a BASRI-lumbar score of 3 or higher were 3.4 (77% chance to have axially progressive disease). Presence of uveitis increased these odds to 93%. Only 15% of female patients with AS had EAA, and the absence of peripheral arthritis was the only clinical measure associated with EAA in this group.
CONCLUSION: EAA was more frequent in men with AS than in women. Absence of peripheral arthritis, HLA-B27 positivity, and uveitis were associated with multiple syndesmophytes or fusion of multiple vertebrae of the lumbar vertebrae.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2010 |
---|---|
Erschienen: |
2010 |
Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
---|---|
Enthalten in: |
The Journal of rheumatology - 37(2010), 11 vom: 15. Nov., Seite 2356-61 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Atagunduz, Pamir [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Completed 11.02.2011 Date Revised 25.11.2016 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.3899/jrheum.100094 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM201591707 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM201591707 | ||
003 | DE-627 | ||
005 | 20231223222726.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231223s2010 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3899/jrheum.100094 |2 doi | |
028 | 5 | 2 | |a pubmed24n0672.xml |
035 | |a (DE-627)NLM201591707 | ||
035 | |a (NLM)20843901 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Atagunduz, Pamir |e verfasserin |4 aut | |
245 | 1 | 0 | |a Determinants of early radiographic progression in ankylosing spondylitis |
264 | 1 | |c 2010 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 11.02.2011 | ||
500 | |a Date Revised 25.11.2016 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a OBJECTIVE: To investigate the demographic and clinical characteristics associated with early, extensive radiographic changes in ankylosing spondylitis (AS) | ||
520 | |a METHODS: Radiographic severity was assessed cross-sectionally in 235 patients with AS using the Bath AS Radiological Index spine score (BASRI-s). Patients with extensive radiographic changes on the lumbar portion of BASRI-s were defined as the early axial ankylosis (EAA) Group. ANCOVA and logistic regression analyses were used to identify factors affecting EAA | ||
520 | |a RESULTS: Most study patients were men (139/235, 59.0%). Mean disease duration was 12.4 ± 9.3 years. Fifteen percent of women and 34.8% of men with AS were in the EAA group. HLA-B27-positive men with AS had significantly higher BASRI-lumbar scores, while HLA-B27 had no effect on radiographic progression of axial disease in women with AS. Peripheral joint involvement was associated with slow radiographic progression. Hip involvement had no effect on axial progression but uveitis was more frequent in the male EAA group. The odds for an HLA-B27-positive male patient with AS who did not have peripheral arthritis of having a BASRI-lumbar score of 3 or higher were 3.4 (77% chance to have axially progressive disease). Presence of uveitis increased these odds to 93%. Only 15% of female patients with AS had EAA, and the absence of peripheral arthritis was the only clinical measure associated with EAA in this group | ||
520 | |a CONCLUSION: EAA was more frequent in men with AS than in women. Absence of peripheral arthritis, HLA-B27 positivity, and uveitis were associated with multiple syndesmophytes or fusion of multiple vertebrae of the lumbar vertebrae | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a HLA-B27 Antigen |2 NLM | |
700 | 1 | |a Aydin, Sibel Zehra |e verfasserin |4 aut | |
700 | 1 | |a Bahadir, Cengiz |e verfasserin |4 aut | |
700 | 1 | |a Erer, Burak |e verfasserin |4 aut | |
700 | 1 | |a Direskeneli, Haner |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t The Journal of rheumatology |d 1983 |g 37(2010), 11 vom: 15. Nov., Seite 2356-61 |w (DE-627)NLM000019593 |x 1499-2752 |7 nnns |
773 | 1 | 8 | |g volume:37 |g year:2010 |g number:11 |g day:15 |g month:11 |g pages:2356-61 |
856 | 4 | 0 | |u http://dx.doi.org/10.3899/jrheum.100094 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 37 |j 2010 |e 11 |b 15 |c 11 |h 2356-61 |