Multiplexed NMR : an automated CapNMR dual-sample probe
A new generation of microscale, nuclear magnetic resonance (CapNMR) probe technology employs two independent detection elements to accommodate two samples simultaneously. Each detection element in the dual-sample CapNMR probe (DSP) delivers the same spectral resolution and S/N as in a CapNMR probe configured to accommodate one sample at a time. A high degree of electrical isolation allows the DSP to be used in a variety of data acquisition modes. Both samples are shimmed simultaneously to achieve high spectral resolution for simultaneous data acquisition, or alternatively, a flowcell-specific shim set is readily called via spectrometer subroutines to enable acquisition from one sample while the other is being loaded. An automation system accommodates loading of two samples via dual injection ports on an autosampler and two completely independent flowpaths leading to dedicated flowcells in the DSP probe.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
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| Enthalten in: |
Analytical chemistry - 82(2010), 17 vom: 01. Sept., Seite 7227-36 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Norcross, James A [VerfasserIn] |
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Date Completed 04.01.2011 Date Revised 20.10.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1021/ac101003f |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM200051415 |
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| 245 | 1 | 0 | |a Multiplexed NMR |b an automated CapNMR dual-sample probe |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A new generation of microscale, nuclear magnetic resonance (CapNMR) probe technology employs two independent detection elements to accommodate two samples simultaneously. Each detection element in the dual-sample CapNMR probe (DSP) delivers the same spectral resolution and S/N as in a CapNMR probe configured to accommodate one sample at a time. A high degree of electrical isolation allows the DSP to be used in a variety of data acquisition modes. Both samples are shimmed simultaneously to achieve high spectral resolution for simultaneous data acquisition, or alternatively, a flowcell-specific shim set is readily called via spectrometer subroutines to enable acquisition from one sample while the other is being loaded. An automation system accommodates loading of two samples via dual injection ports on an autosampler and two completely independent flowpaths leading to dedicated flowcells in the DSP probe | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 700 | 1 | |a Milling, Craig T |e verfasserin |4 aut | |
| 700 | 1 | |a Olson, Dean L |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Duanxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Audrieth, Anthony |e verfasserin |4 aut | |
| 700 | 1 | |a Albrecht, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Ruan, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Likos, John |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Claude |e verfasserin |4 aut | |
| 700 | 1 | |a Peck, Timothy L |e verfasserin |4 aut | |
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