Correlation between the levels of circulating adhesion molecules and atherosclerosis in hypertensive type-2 diabetic patients
Endothelial dysfunction is a common feature in type-2 diabetic patients and in hypertension, and is associated with inflammation, increased levels of circulating soluble adhesion molecules, and atherosclerosis. The aim of this study was to evaluate the relationship between the levels of circulating soluble adhesion molecules and the degree of atherosclerosis in hypertensive type-2 diabetic patients. We studied 30 hypertensive type-2 diabetic patients in whom VCAM-1, ICAM-1, and E-selectin were measured by ELISA. Additionally, the intimal-medial thickness of both the common and internal carotid arteries was measured (B-mode ultrasound). The levels of circulating adhesion molecules and maximal carotid artery intimal-medial thicknesses were correlated using the Spearman correlation coefficient test. Statistical analysis was performed with ANOVA. We found significant correlations between ICAM-1 (r = 0.5) levels and maximal carotid artery intimal-medial thickness these patients. No correlation was observed with E-selectin and VCAM-1. Our results suggest that ICAM-1 is associated and correlated with the degree of atherosclerosis in type-2 diabetic hypertensive patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Clinical and experimental hypertension (New York, N.Y. : 1993) - 32(2010), 5 vom: 01., Seite 308-10 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rubio-Guerra, Alberto Francisco [VerfasserIn] |
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| Links: |
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| Themen: |
126547-89-5 |
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| Anmerkungen: |
Date Completed 05.11.2010 Date Revised 25.11.2016 published: Print Citation Status MEDLINE |
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| doi: |
10.3109/10641960903443533 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM199872430 |
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| 100 | 1 | |a Rubio-Guerra, Alberto Francisco |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Correlation between the levels of circulating adhesion molecules and atherosclerosis in hypertensive type-2 diabetic patients |
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| 500 | |a Date Completed 05.11.2010 | ||
| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Endothelial dysfunction is a common feature in type-2 diabetic patients and in hypertension, and is associated with inflammation, increased levels of circulating soluble adhesion molecules, and atherosclerosis. The aim of this study was to evaluate the relationship between the levels of circulating soluble adhesion molecules and the degree of atherosclerosis in hypertensive type-2 diabetic patients. We studied 30 hypertensive type-2 diabetic patients in whom VCAM-1, ICAM-1, and E-selectin were measured by ELISA. Additionally, the intimal-medial thickness of both the common and internal carotid arteries was measured (B-mode ultrasound). The levels of circulating adhesion molecules and maximal carotid artery intimal-medial thicknesses were correlated using the Spearman correlation coefficient test. Statistical analysis was performed with ANOVA. We found significant correlations between ICAM-1 (r = 0.5) levels and maximal carotid artery intimal-medial thickness these patients. No correlation was observed with E-selectin and VCAM-1. Our results suggest that ICAM-1 is associated and correlated with the degree of atherosclerosis in type-2 diabetic hypertensive patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a E-Selectin |2 NLM | |
| 650 | 7 | |a Vascular Cell Adhesion Molecule-1 |2 NLM | |
| 650 | 7 | |a Intercellular Adhesion Molecule-1 |2 NLM | |
| 650 | 7 | |a 126547-89-5 |2 NLM | |
| 700 | 1 | |a Vargas-Robles, Hilda |e verfasserin |4 aut | |
| 700 | 1 | |a Serrano, Alberto Maceda |e verfasserin |4 aut | |
| 700 | 1 | |a Vargas-Ayala, German |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez-Lopez, Leticia |e verfasserin |4 aut | |
| 700 | 1 | |a Escalante-Acosta, Bruno Alfonso |e verfasserin |4 aut | |
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