microRNA-181b targets MLK2 in HL-60 cells
microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Science China. Life sciences - 53(2010), 1 vom: 28. Jan., Seite 101-106 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Hong [VerfasserIn] |
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| Links: |
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| Themen: |
EC 2.7.11.25 |
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| Anmerkungen: |
Date Completed 02.11.2010 Date Revised 10.01.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11427-010-0002-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM199281602 |
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| 520 | |a microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs | ||
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