Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L
Successive extraction of the dried leaves of Melastoma malabathricum, followed by purification using repeated chromatographic techniques, yielded six compounds, including two amides, auranamide and patriscabratine, a triterpene, alpha-amyrin, and three flavonoids, quercitrin, quercetin and kaempferol-3-O-(2'',6''-di-O-p-trans-coumaroyl)-beta-glucoside. Their structures were elucidated by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. These three phenolic constituents were found to be active as free radical scavengers, with quercetin being the strongest radical scavenger, having an IC(50) value of 0.69 microM in the UV method. Quercitrin and kaempferol-3-O-(2'',6''-di-O-p-trans-coumaroyl)-beta-glucoside showed moderate radical scavenging, with IC(50) values of 74.1 and 108.8 microM, respectively.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Journal of natural medicines - 64(2010), 4 vom: 21. Okt., Seite 492-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sirat, Hasnah M [VerfasserIn] |
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| Links: |
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| Themen: |
Amides |
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| Anmerkungen: |
Date Completed 06.06.2011 Date Revised 20.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11418-010-0431-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM199144974 |
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| 245 | 1 | 0 | |a Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L |
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| 500 | |a Date Completed 06.06.2011 | ||
| 500 | |a Date Revised 20.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Successive extraction of the dried leaves of Melastoma malabathricum, followed by purification using repeated chromatographic techniques, yielded six compounds, including two amides, auranamide and patriscabratine, a triterpene, alpha-amyrin, and three flavonoids, quercitrin, quercetin and kaempferol-3-O-(2'',6''-di-O-p-trans-coumaroyl)-beta-glucoside. Their structures were elucidated by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. These three phenolic constituents were found to be active as free radical scavengers, with quercetin being the strongest radical scavenger, having an IC(50) value of 0.69 microM in the UV method. Quercitrin and kaempferol-3-O-(2'',6''-di-O-p-trans-coumaroyl)-beta-glucoside showed moderate radical scavenging, with IC(50) values of 74.1 and 108.8 microM, respectively | ||
| 650 | 4 | |a Comparative Study | |
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| 650 | 7 | |a Amides |2 NLM | |
| 650 | 7 | |a Antioxidants |2 NLM | |
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| 650 | 7 | |a Plant Extracts |2 NLM | |
| 650 | 7 | |a Triterpenes |2 NLM | |
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| 700 | 1 | |a Ahmad, Farediah |e verfasserin |4 aut | |
| 700 | 1 | |a Takayama, Hiromitsu |e verfasserin |4 aut | |
| 700 | 1 | |a Kitajima, Mariko |e verfasserin |4 aut | |
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