Evaluation of an acellular pertussis, diphtheria, tetanus, inactivated poliovirus, Hib-conjugate combined vaccine (Pentaxim) at 2, 4, and 6 months of age plus hepatitis B vaccine at birth, 2, and 6 months of age in infants in Thailand
The objective of this study was to evaluate the immunogenicity and safety of a pentavalent vaccine (Pentaxim) containing diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Hib polysaccharide-conjugate (DTaP-IPV//PRP-T) antigens, in Thai children. One hundred eighty-six infants who had received a hepatitis B vaccine at birth were given a pentavalent vaccine at 2, 4 and 6 months of age and a hepatitis B vaccine concomitantly at 2 and 6 months of age. Immunogenicity was high for each vaccine antigen. The study vaccine was well tolerated and side effects were few. After the third dose, 100% of subjects had an anti-PRP > or = 0.15 microg/ml and 96.5% > or = 1.0 microg/ml; the anti-PRP GMT was 9.53 microg/ml. Seroprotective rates for diphtheria and tetanus (> or = 0.01 IU/ml) were 99.4% and 100%, respectively, and 100% for all three poliovirus types (> or = 8 1/dil U). The vaccine response rates to pertussis antigens (a 4-fold increase in antibody titer were 94.1% for PT and 93.0% for FHA. The DTaP-IPV//PRP-T vaccine given at 2, 4 and 6 months of age concomitantly with a monovalent hepatitis B vaccine, was well tolerated and highly immunogenic for primary immunization of infants in Thailand.
Medienart: |
Artikel |
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Erscheinungsjahr: |
2010 |
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Erschienen: |
2010 |
Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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Enthalten in: |
The Southeast Asian journal of tropical medicine and public health - 41(2010), 2 vom: 03. März, Seite 450-62 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Thisyakorn, Usa [VerfasserIn] |
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Anmerkungen: |
Date Completed 07.10.2010 Date Revised 10.12.2019 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM199108323 |
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245 | 1 | 0 | |a Evaluation of an acellular pertussis, diphtheria, tetanus, inactivated poliovirus, Hib-conjugate combined vaccine (Pentaxim) at 2, 4, and 6 months of age plus hepatitis B vaccine at birth, 2, and 6 months of age in infants in Thailand |
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520 | |a The objective of this study was to evaluate the immunogenicity and safety of a pentavalent vaccine (Pentaxim) containing diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Hib polysaccharide-conjugate (DTaP-IPV//PRP-T) antigens, in Thai children. One hundred eighty-six infants who had received a hepatitis B vaccine at birth were given a pentavalent vaccine at 2, 4 and 6 months of age and a hepatitis B vaccine concomitantly at 2 and 6 months of age. Immunogenicity was high for each vaccine antigen. The study vaccine was well tolerated and side effects were few. After the third dose, 100% of subjects had an anti-PRP > or = 0.15 microg/ml and 96.5% > or = 1.0 microg/ml; the anti-PRP GMT was 9.53 microg/ml. Seroprotective rates for diphtheria and tetanus (> or = 0.01 IU/ml) were 99.4% and 100%, respectively, and 100% for all three poliovirus types (> or = 8 1/dil U). The vaccine response rates to pertussis antigens (a 4-fold increase in antibody titer were 94.1% for PT and 93.0% for FHA. The DTaP-IPV//PRP-T vaccine given at 2, 4 and 6 months of age concomitantly with a monovalent hepatitis B vaccine, was well tolerated and highly immunogenic for primary immunization of infants in Thailand | ||
650 | 4 | |a Evaluation Study | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 7 | |a Diphtheria-Tetanus-acellular Pertussis Vaccines |2 NLM | |
650 | 7 | |a Haemophilus Vaccines |2 NLM | |
650 | 7 | |a Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate |2 NLM | |
650 | 7 | |a Hepatitis B Vaccines |2 NLM | |
650 | 7 | |a Poliovirus Vaccines |2 NLM | |
650 | 7 | |a Tetanus Toxoid |2 NLM | |
650 | 7 | |a Vaccines, Conjugate |2 NLM | |
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700 | 1 | |a Pancharoen, Chitsanu |e verfasserin |4 aut | |
700 | 1 | |a Chuenkitmongkol, Sunate |e verfasserin |4 aut | |
700 | 1 | |a Ortiz, Esteban |e verfasserin |4 aut | |
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