Outcomes of long-term combined treatment in follicular thyroid carcinoma
UNLABELLED: The aim was to analyze the impact of combined treatment (thyroidectomy + radioactive iodine treatment + hormonotherapy with thyroxine) on the outcomes of patients with follicular thyroid carcinoma.
MATERIAL AND METHODS: This retrospective study included 448 patients with follicular carcinoma (394 females, 54 males, mean age of 48 years (95% CI, 46-50 years) who were treated at the Institute of Oncology, Vilnius University, from 1982 to 2006. All the patients underwent thyroidectomy. Hypothyroid patients 3-12 weeks after surgical treatment were treated with moderate radioiodine doses (1.11-3.7 GBq), and these doses were administered every 3-4 months. The patients with follicular thyroid carcinoma were given suppressive doses of thyroxine after combined treatment. The patients treated were regularly observed by gamma camera; every 6-12 months, serum thyroglobulin was evaluated.
RESULTS: The remnants of thyroid tissue were detected in all 448 patients after thyroidectomy and radioiodine therapy. Radioiodine at mean total doses of 5.6+/-0.2 GBq was used to destroy the remnants of thyroid tissue. For patients with disseminated forms of follicular thyroid carcinoma, mean total radioiodine doses of 19.5+/-3.1 GBq were used. Majority (91.2%) of the patients were euthyroid or hyperthyroid after the treatment with thyroid hormone. All the patients treated had the level of serum thyroglobulin of 1.1+/-0.2 ng/mL. The overall 10-, 20-, and 30-year survival of patients with follicular thyroid cancer, who received combined treatment, was 91.2%, 81.9%, and 77.1%, respectively.
CONCLUSION: Combined treatment (thyroidectomy + radioactive iodine treatment + hormonotherapy with thyroxine) administered to the patients with follicular thyroid carcinoma is highly effective, because overall 10-, 20-, 30-year survival was 91.2%, 81.9%, 77.1%, respectively.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
|---|---|
| Enthalten in: |
Medicina (Kaunas, Lithuania) - 46(2010), 4 vom: 07., Seite 268-74 |
| Sprache: |
Litauisch |
|---|
| Weiterer Titel: |
Folikulinio skydliaukes vezio ilgalaikio kompleksinio gydymo rezultatai |
|---|
| Beteiligte Personen: |
Baranauskas, Zenonas [VerfasserIn] |
|---|
| Themen: |
9010-34-8 |
|---|
| Anmerkungen: |
Date Completed 14.10.2010 Date Revised 14.06.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM199040729 |
|---|
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| 100 | 1 | |a Baranauskas, Zenonas |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Outcomes of long-term combined treatment in follicular thyroid carcinoma |
| 246 | 3 | 3 | |a Folikulinio skydliaukes vezio ilgalaikio kompleksinio gydymo rezultatai |
| 264 | 1 | |c 2010 | |
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| 500 | |a Date Completed 14.10.2010 | ||
| 500 | |a Date Revised 14.06.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a UNLABELLED: The aim was to analyze the impact of combined treatment (thyroidectomy + radioactive iodine treatment + hormonotherapy with thyroxine) on the outcomes of patients with follicular thyroid carcinoma | ||
| 520 | |a MATERIAL AND METHODS: This retrospective study included 448 patients with follicular carcinoma (394 females, 54 males, mean age of 48 years (95% CI, 46-50 years) who were treated at the Institute of Oncology, Vilnius University, from 1982 to 2006. All the patients underwent thyroidectomy. Hypothyroid patients 3-12 weeks after surgical treatment were treated with moderate radioiodine doses (1.11-3.7 GBq), and these doses were administered every 3-4 months. The patients with follicular thyroid carcinoma were given suppressive doses of thyroxine after combined treatment. The patients treated were regularly observed by gamma camera; every 6-12 months, serum thyroglobulin was evaluated | ||
| 520 | |a RESULTS: The remnants of thyroid tissue were detected in all 448 patients after thyroidectomy and radioiodine therapy. Radioiodine at mean total doses of 5.6+/-0.2 GBq was used to destroy the remnants of thyroid tissue. For patients with disseminated forms of follicular thyroid carcinoma, mean total radioiodine doses of 19.5+/-3.1 GBq were used. Majority (91.2%) of the patients were euthyroid or hyperthyroid after the treatment with thyroid hormone. All the patients treated had the level of serum thyroglobulin of 1.1+/-0.2 ng/mL. The overall 10-, 20-, and 30-year survival of patients with follicular thyroid cancer, who received combined treatment, was 91.2%, 81.9%, and 77.1%, respectively | ||
| 520 | |a CONCLUSION: Combined treatment (thyroidectomy + radioactive iodine treatment + hormonotherapy with thyroxine) administered to the patients with follicular thyroid carcinoma is highly effective, because overall 10-, 20-, 30-year survival was 91.2%, 81.9%, 77.1%, respectively | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Iodine Radioisotopes |2 NLM | |
| 650 | 7 | |a Thyroglobulin |2 NLM | |
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| 700 | 1 | |a Valuckas, Konstantinas Povilas |e verfasserin |4 aut | |
| 700 | 1 | |a Tiskevicius, Sigitas |e verfasserin |4 aut | |
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