Cutaneous CD4+ CD56+ hematologic malignancies
Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved..
BACKGROUND: Hematologic malignancies expressing CD4 and CD56 are most commonly associated with the recently described CD4(+) CD56(+) hematodermic neoplasm.
METHODS: Thirteen cases of CD4(+) CD56(+) hematologic malignancies were prospectively encountered in the routine and referral practices of the authors.
RESULTS: Patients 1 and 2 were elderly men exhibiting an acute onset of skin, bone-marrow, and peripheral blood involvement, both dying of their disease within less than 12 months. CD3(+) phenotype and a clonal T-cell receptor beta rearrangement indicated categorization as a CD4(+) natural killer T-cell lymphoma. Patient 3 developed a CD56(+) anaplastic large cell lymphoma and is without disease after excision and radiation. Indolent CD4(+) CD56(+) poikilodermatous mycosis fungoides defined case 4. There were 7 patients with CD123(+) CD4(+) CD56(+) hematodermic neoplasm, 4 dying within 18 months of presentation with peripheral blood/marrow involvement in 6 of the 7 cases. Two patients with granulocytic sarcoma dying within 100 days of presentation defined the last two cases.
LIMITATIONS: There were relatively small numbers in each of the categories and the follow-up was limited in those cases where death was not reported.
CONCLUSION: Cutaneous malignancies composed of CD4(+) CD56(+) hematopoietic cells define a varied group and oftentimes have an aggressive clinical course although not in every case.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
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| Enthalten in: |
Journal of the American Academy of Dermatology - 63(2010), 2 vom: 15. Aug., Seite 292-308 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Magro, Cynthia M [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 05.08.2010 Date Revised 16.11.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jaad.2009.08.044 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM198754000 |
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| 245 | 1 | 0 | |a Cutaneous CD4+ CD56+ hematologic malignancies |
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| 500 | |a Date Revised 16.11.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Hematologic malignancies expressing CD4 and CD56 are most commonly associated with the recently described CD4(+) CD56(+) hematodermic neoplasm | ||
| 520 | |a METHODS: Thirteen cases of CD4(+) CD56(+) hematologic malignancies were prospectively encountered in the routine and referral practices of the authors | ||
| 520 | |a RESULTS: Patients 1 and 2 were elderly men exhibiting an acute onset of skin, bone-marrow, and peripheral blood involvement, both dying of their disease within less than 12 months. CD3(+) phenotype and a clonal T-cell receptor beta rearrangement indicated categorization as a CD4(+) natural killer T-cell lymphoma. Patient 3 developed a CD56(+) anaplastic large cell lymphoma and is without disease after excision and radiation. Indolent CD4(+) CD56(+) poikilodermatous mycosis fungoides defined case 4. There were 7 patients with CD123(+) CD4(+) CD56(+) hematodermic neoplasm, 4 dying within 18 months of presentation with peripheral blood/marrow involvement in 6 of the 7 cases. Two patients with granulocytic sarcoma dying within 100 days of presentation defined the last two cases | ||
| 520 | |a LIMITATIONS: There were relatively small numbers in each of the categories and the follow-up was limited in those cases where death was not reported | ||
| 520 | |a CONCLUSION: Cutaneous malignancies composed of CD4(+) CD56(+) hematopoietic cells define a varied group and oftentimes have an aggressive clinical course although not in every case | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a CD4 Antigens |2 NLM | |
| 650 | 7 | |a CD56 Antigen |2 NLM | |
| 700 | 1 | |a Porcu, Pierluigi |e verfasserin |4 aut | |
| 700 | 1 | |a Schaefer, Jochen |e verfasserin |4 aut | |
| 700 | 1 | |a Erter, Jack W |e verfasserin |4 aut | |
| 700 | 1 | |a Furman, Richard R |e verfasserin |4 aut | |
| 700 | 1 | |a Shitabata, Paul K |e verfasserin |4 aut | |
| 700 | 1 | |a Crowson, A Neil |e verfasserin |4 aut | |
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