Contrast-induced acute kidney injury (CI-AKI) following intra-arterial administration of iodinated contrast media
BACKGROUND: We report the incidence of contrast-induced acute kidney injury (CI-AKI) following administration of iodixanol or low-osmolar contrast media (LOCM) in patients for suspected peripheral arterial occlusive disease (PAOD) undergoing intra-arterial digital angiography (IA-DSA).
METHODS: IA-DSA was performed according to site standard for contrast agent type and volume following computed tomography (CT) of the abdominal aortoiliac and lower extremity arteries and a washout period of at least 3 days. Serum creatinine was measured at baseline and 24 ± 4 hours after contrast administration. CI-AKI was defined as laboratory increase of serum creatinine value =25% from baseline measurement at 24 hours. The incidence of CI-AKI was analyzed with chi-square statistics.
RESULTS: Of the 250 patients who underwent IA-DSA with complete data for analysis, 147 (58.8%) received iodixanol and 103 (41.2%) received LOCM (iopamidol, 91; ioversol, 7; iohexol, 3; iopromide, 2). Baseline mean serum creatinine was statistically higher for iodixanol compared with LOCM (100 vs. 82.7 µmol/L; p=0.0124). CI-AKI occurred in 8 patients (5.4%) with iodixanol and 14 patients (13.6%) with LOCM (p=0.025). Further analysis showed that iopamidol administration was responsible for the 13 out of 14 cases of CI-AKI in LOCM patients.
CONCLUSIONS: In patients with suspected PAOD undergoing IA-DSA, the incidence of CI-AKI at 24 hours following contrast administration was significantly less for patients who received iodixanol compared with various LOCM; this difference was primarily driven by iopamidol.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Journal of nephrology - 23(2010), 6 vom: 15. Nov., Seite 658-66 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Karlsberg, Ronald P [VerfasserIn] |
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| Themen: |
AYI8EX34EU |
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| Anmerkungen: |
Date Completed 20.01.2011 Date Revised 25.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM198741928 |
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| 041 | |a eng | ||
| 100 | 1 | |a Karlsberg, Ronald P |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Contrast-induced acute kidney injury (CI-AKI) following intra-arterial administration of iodinated contrast media |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
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| 500 | |a Date Completed 20.01.2011 | ||
| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: We report the incidence of contrast-induced acute kidney injury (CI-AKI) following administration of iodixanol or low-osmolar contrast media (LOCM) in patients for suspected peripheral arterial occlusive disease (PAOD) undergoing intra-arterial digital angiography (IA-DSA) | ||
| 520 | |a METHODS: IA-DSA was performed according to site standard for contrast agent type and volume following computed tomography (CT) of the abdominal aortoiliac and lower extremity arteries and a washout period of at least 3 days. Serum creatinine was measured at baseline and 24 ± 4 hours after contrast administration. CI-AKI was defined as laboratory increase of serum creatinine value =25% from baseline measurement at 24 hours. The incidence of CI-AKI was analyzed with chi-square statistics | ||
| 520 | |a RESULTS: Of the 250 patients who underwent IA-DSA with complete data for analysis, 147 (58.8%) received iodixanol and 103 (41.2%) received LOCM (iopamidol, 91; ioversol, 7; iohexol, 3; iopromide, 2). Baseline mean serum creatinine was statistically higher for iodixanol compared with LOCM (100 vs. 82.7 µmol/L; p=0.0124). CI-AKI occurred in 8 patients (5.4%) with iodixanol and 14 patients (13.6%) with LOCM (p=0.025). Further analysis showed that iopamidol administration was responsible for the 13 out of 14 cases of CI-AKI in LOCM patients | ||
| 520 | |a CONCLUSIONS: In patients with suspected PAOD undergoing IA-DSA, the incidence of CI-AKI at 24 hours following contrast administration was significantly less for patients who received iodixanol compared with various LOCM; this difference was primarily driven by iopamidol | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Contrast Media |2 NLM | |
| 650 | 7 | |a Triiodobenzoic Acids |2 NLM | |
| 650 | 7 | |a Creatinine |2 NLM | |
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| 700 | 1 | |a Dohad, Suhail Y |e verfasserin |4 aut | |
| 700 | 1 | |a Sheng, Rubin |e verfasserin |4 aut | |
| 700 | 0 | |a Iodixanol Peripheral CTA Study Investigator Panel |e verfasserin |4 aut | |
| 700 | 1 | |a Bellinger, Raye |e investigator |4 oth | |
| 700 | 1 | |a Yonehiro, Layne |e investigator |4 oth | |
| 700 | 1 | |a Lu, David S |e investigator |4 oth | |
| 700 | 1 | |a Weiland, Frederick |e investigator |4 oth | |
| 700 | 1 | |a Castaneda-Zuniga, Wilfrido |e investigator |4 oth | |
| 700 | 1 | |a Smith, J Kevin |e investigator |4 oth | |
| 700 | 1 | |a Andriole, Joseph |e investigator |4 oth | |
| 700 | 1 | |a Cambier, Patrick |e investigator |4 oth | |
| 700 | 1 | |a Murphy, Kenneth |e investigator |4 oth | |
| 700 | 1 | |a Sam, Albert |c 2nd |e investigator |4 oth | |
| 700 | 1 | |a Nosher, John |e investigator |4 oth | |
| 700 | 1 | |a Colleran, John |e investigator |4 oth | |
| 700 | 1 | |a Rose, Steven |e investigator |4 oth | |
| 700 | 1 | |a Singh, H Paul |e investigator |4 oth | |
| 700 | 1 | |a Benko, Andrew |e investigator |4 oth | |
| 700 | 1 | |a Reid, John |e investigator |4 oth | |
| 700 | 1 | |a Wicky, Stephan |e investigator |4 oth | |
| 700 | 1 | |a Bashir, Riyaz |e investigator |4 oth | |
| 700 | 1 | |a Harris, Linda |e investigator |4 oth | |
| 700 | 1 | |a Johnson, Kenneth |e investigator |4 oth | |
| 700 | 1 | |a Mishkel, Gregory |e investigator |4 oth | |
| 700 | 1 | |a Brantley, Steven |e investigator |4 oth | |
| 700 | 1 | |a Prasad, Srinivasa |e investigator |4 oth | |
| 700 | 1 | |a Sands, Mark |e investigator |4 oth | |
| 700 | 1 | |a Needleman, Laurence |e investigator |4 oth | |
| 700 | 1 | |a Catanzano, Tara |e investigator |4 oth | |
| 700 | 1 | |a Beasley, Robert |e investigator |4 oth | |
| 700 | 1 | |a Richardson, Huger |e investigator |4 oth | |
| 700 | 1 | |a Kay, Dennis |e investigator |4 oth | |
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