Juxtaluminal hypoechoic area in ultrasonic images of carotid plaques and hemispheric symptoms
Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved..
OBJECTIVES: The aim was to determine the diagnostic value of a juxtaluminal black (hypoechoic) area without a visible echogenic cap (JBA) in ultrasonic images of internal carotid artery plaques.
METHODS: Ultrasonic images of plaques from 324 patients with asymptomatic (n = 139) and symptomatic (n = 185) internal carotid 50% to 99% stenosis in relation to the bulb (European Carotid Surgery Trial) referred for duplex scanning were studied. The JBA in mm(2) and the gray-scale median (GSM) were obtained after image normalization. Cut-off points for GSM and JBA (combined highest sensitivity with highest specificity) were determined from receiver operator characteristic (ROC) curves.
RESULTS: JBA >or= 8 mm(2) was associated with a high prevalence of symptomatic plaques in all grades of stenosis. In a multiple logistic regression model, increasing stenosis (mild, moderate, severe), GSM <or= 15 and JBA >or= 8 mm(2) were independent predictors of the presence of hemispheric symptoms. This model could identify a high-risk group of 188 plaques that contained 142 (77%) of the 185 symptomatic plaques (odds ratio [OR], 6.7; 95% confidence interval [CI], 4.08-10.91), (P < .001), (sensitivity: 77%; specificity 66%; positive predictive value 75%; negative predictive value 68%).
CONCLUSIONS: The results of this study indicate the diagnostic value and for the first time suggest a cut-off point of 8 mm(2) for JBA. This cut-off point needs to be validated in other groups and then applied to prospective studies of asymptomatic patients.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Journal of vascular surgery - 52(2010), 1 vom: 13. Juli, Seite 69-76 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Griffin, Maura B [VerfasserIn] |
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| Anmerkungen: |
Date Completed 10.08.2010 Date Revised 25.11.2016 published: Print ErratumIn: J Vasc Surg. 2010 Nov;52(5):1430 Citation Status MEDLINE |
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| doi: |
10.1016/j.jvs.2010.02.265 |
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| funding: |
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| PPN (Katalog-ID): |
NLM198717407 |
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| 100 | 1 | |a Griffin, Maura B |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Juxtaluminal hypoechoic area in ultrasonic images of carotid plaques and hemispheric symptoms |
| 264 | 1 | |c 2010 | |
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| 500 | |a Date Completed 10.08.2010 | ||
| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: J Vasc Surg. 2010 Nov;52(5):1430 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: The aim was to determine the diagnostic value of a juxtaluminal black (hypoechoic) area without a visible echogenic cap (JBA) in ultrasonic images of internal carotid artery plaques | ||
| 520 | |a METHODS: Ultrasonic images of plaques from 324 patients with asymptomatic (n = 139) and symptomatic (n = 185) internal carotid 50% to 99% stenosis in relation to the bulb (European Carotid Surgery Trial) referred for duplex scanning were studied. The JBA in mm(2) and the gray-scale median (GSM) were obtained after image normalization. Cut-off points for GSM and JBA (combined highest sensitivity with highest specificity) were determined from receiver operator characteristic (ROC) curves | ||
| 520 | |a RESULTS: JBA >or= 8 mm(2) was associated with a high prevalence of symptomatic plaques in all grades of stenosis. In a multiple logistic regression model, increasing stenosis (mild, moderate, severe), GSM <or= 15 and JBA >or= 8 mm(2) were independent predictors of the presence of hemispheric symptoms. This model could identify a high-risk group of 188 plaques that contained 142 (77%) of the 185 symptomatic plaques (odds ratio [OR], 6.7; 95% confidence interval [CI], 4.08-10.91), (P < .001), (sensitivity: 77%; specificity 66%; positive predictive value 75%; negative predictive value 68%) | ||
| 520 | |a CONCLUSIONS: The results of this study indicate the diagnostic value and for the first time suggest a cut-off point of 8 mm(2) for JBA. This cut-off point needs to be validated in other groups and then applied to prospective studies of asymptomatic patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Kyriacou, Efthyvoulous |e verfasserin |4 aut | |
| 700 | 1 | |a Pattichis, Costas |e verfasserin |4 aut | |
| 700 | 1 | |a Bond, Dawn |e verfasserin |4 aut | |
| 700 | 1 | |a Kakkos, Stavros K |e verfasserin |4 aut | |
| 700 | 1 | |a Sabetai, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Geroulakos, George |e verfasserin |4 aut | |
| 700 | 1 | |a Georgiou, Niki |e verfasserin |4 aut | |
| 700 | 1 | |a Doré, Caroline J |e verfasserin |4 aut | |
| 700 | 1 | |a Nicolaides, Andrew |e verfasserin |4 aut | |
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